Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
TBC1D25 (OATL1) binds ATG8 homologues
Stable Identifier
R-HSA-8854588
Type
Reaction [binding]
Species
Homo sapiens
Compartment
autophagosome membrane
,
autophagosome
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Rab regulation of trafficking (Homo sapiens)
TBC/RABGAPs (Homo sapiens)
TBC1D25 (OATL1) binds ATG8 homologues (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
TBC (Tre2/Bub2/Cdc16) domain family member 25 (TBC1D25 also referred as OATL1), a putative GTPase activating protein (GAP), is recruited to autophagosomes through an interaction with ATG8 homologues (LC3, GABARAP and GATE-16), and is involved in the fusion between autophagosomes and lysosomes through its GAP activity. OATL1 delays autophagosomal maturation by inhibiting the encounter between autophagosomes and lysosomes (Itoh et al. 2011).
Literature References
PubMed ID
Title
Journal
Year
21383079
OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation
Fukuda, M
,
Itoh, T
,
Uemura, T
,
Waguri, S
,
Kanno, E
J. Cell Biol.
2011
Participants
Input
ATG8 homologues [autophagosome membrane]
(Homo sapiens)
TBC1D25 [autophagosome]
(Homo sapiens)
Output
TBC1D25:ATG8 homoogues [autophagosome membrane]
(Homo sapiens)
Participates
as an event of
TBC/RABGAPs (Homo sapiens)
Orthologous Events
TBC1D25 (OATL1) binds ATG8 homologues (Bos taurus)
TBC1D25 (OATL1) binds ATG8 homologues (Canis familiaris)
TBC1D25 (OATL1) binds ATG8 homologues (Dictyostelium discoideum)
TBC1D25 (OATL1) binds ATG8 homologues (Drosophila melanogaster)
TBC1D25 (OATL1) binds ATG8 homologues (Gallus gallus)
TBC1D25 (OATL1) binds ATG8 homologues (Mus musculus)
TBC1D25 (OATL1) binds ATG8 homologues (Rattus norvegicus)
TBC1D25 (OATL1) binds ATG8 homologues (Saccharomyces cerevisiae)
TBC1D25 (OATL1) binds ATG8 homologues (Schizosaccharomyces pombe)
TBC1D25 (OATL1) binds ATG8 homologues (Sus scrofa)
Authored
Garapati, P V (2016-01-27)
Created
Garapati, P V (2016-01-28)
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text