TBC1D10A (EPI64) stabilizes active ARF6 and also has an additional function in the ARF6-dependent pathway through regulating the levels of active RAB8A. RAB8A is involved in the recycling pathway from endosomes back to the plasma membrane. TBC1D10A binds the Rab8a effector JFC1 and reduces the level of Rab8a:GTP to regulate Rab8a/Arf6-dependent membrane trafficking. TBC1D10A binds JFC1 through its (Slp) homology domain (SHD), and JFC1 can simultaneously interact with active Rab8a (Hokanson & Bretscher 2011).
Bretscher, AP, Hokanson, DE
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