TBC1D10A binds JFC1

Stable Identifier
R-HSA-8854209
Type
Reaction [binding]
Species
Homo sapiens
Compartment
microvillus, microvillus membrane
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TBC1D10A binds JFC1
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TBC1D10A (EPI64) stabilizes active ARF6 and also has an additional function in the ARF6-dependent pathway through regulating the levels of active RAB8A. RAB8A is involved in the recycling pathway from endosomes back to the plasma membrane. TBC1D10A binds the Rab8a effector JFC1 and reduces the level of Rab8a:GTP to regulate Rab8a/Arf6-dependent membrane trafficking. TBC1D10A binds JFC1 through its (Slp) homology domain (SHD), and JFC1 can simultaneously interact with active Rab8a (Hokanson & Bretscher 2011).

Literature References
PubMed ID Title Journal Year
22219378 EPI64 interacts with Slp1/JFC1 to coordinate Rab8a and Arf6 membrane trafficking

Hokanson, DE, Bretscher, AP

Mol. Biol. Cell 2012
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Orthologous Events
TBC1D10A binds JFC1 (Bos taurus)
TBC1D10A binds JFC1 (Canis familiaris)
TBC1D10A binds JFC1 (Danio rerio)
TBC1D10A binds JFC1 (Dictyostelium discoideum)
TBC1D10A binds JFC1 (Gallus gallus)
TBC1D10A binds JFC1 (Mus musculus)
TBC1D10A binds JFC1 (Rattus norvegicus)
TBC1D10A binds JFC1 (Sus scrofa)
Authored
Garapati, P V  (2016-01-27)
Created
Garapati, P V  (2016-01-27)
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