Binding of VENTX to the p16-INK4A-specific CDKN2A promoter stimulates p16-INK4A expression. p16-INK4A acts as an inhibitor of cyclin-dependent kinases CDK4 and CDK6 and prevents CDK4/6-mediated inactivation of the RB1 tumor suppressor. Up-regulation of p16-INK4A contributes to VENTX-mediated cell cycle arrest (Wu et al. 2011). VENTX-mediated cell cycle arrest is implicated as an important step in differentiation of human hematopoietic cells (Gao et al. 2012).
Hager, M, Freeman, MR, Xiao, S, Ke, W, Gao, H, Wu, X, Zhu, Z
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