Binding of VENTX to the promoter of the TP53 (p53) gene stimulates TP53 transcription, resulting in cell cycle arrest that depends on the expression of the downstream TP53 target CDKN1A (Wu et al. 2011). VENTX-mediated cell cycle arrest is implicated as an important step in differentiation of human hematopoietic cells (Gao et al. 2012).
Wu, X, Gao, H, Ke, W, Hager, M, Xiao, S, Freeman, MR, Zhu, Z
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