VENTX stimulates TP53 gene expression

Stable Identifier
R-HSA-8853911
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
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VENTX stimulates TP53 gene expression
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Binding of VENTX to the promoter of the TP53 (p53) gene stimulates TP53 transcription, resulting in cell cycle arrest that depends on the expression of the downstream TP53 target CDKN1A (Wu et al. 2011). VENTX-mediated cell cycle arrest is implicated as an important step in differentiation of human hematopoietic cells (Gao et al. 2012).

Literature References
PubMed ID Title Journal Year
21325273 VentX trans-activates p53 and p16ink4a to regulate cellular senescence

Wu, X, Gao, H, Ke, W, Hager, M, Xiao, S, Freeman, MR, Zhu, Z

J. Biol. Chem. 2011
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Authored
Orlic-Milacic, M  (2019-06-28)
Reviewed
Vegi, NM  (2019-10-18)
Created
Orlic-Milacic, M  (2016-01-25)