GDNF stimulation of neuronal cells induces the assembly of a large protein complex containing RET, GRB2 and tyrosine-phosphorylated SHC1, p85 subunit of (PI3K), GAB2 (GAB1 in Hayashi et al. 2000) and Tyrosine-protein phosphatase non-receptor type 11 (PTPN11, SHP-2) (Besset et al. 2000). RET binds SHC1 via phosphorylated tyrosine-1062 (Asai et al. 1996, Arighi et al. 1997).
Murakami, H, Asai, N, Takahashi, M, Iwashita, T
Asai, N, Murakami, H, Ohiwa, M, Takahashi, M, Iwata, Y, Funahashi, H, Iwashita, T, Imai, T, Takagi, H
Alberti, L, Piutti, C, Pasini, B, Ghizzoni, S, Torriti, F, Bongarzone, I, Pelicci, G, Rizzetti, MG, Arighi, E, Pierotti, MA, Borrello, MG
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