OTULIN,USP5 cleaves UBB yielding ubiquitin

Stable Identifier
R-HSA-8853529
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The UBB poly-protein contains 3 Ubiquitin monomers that are released by proteolysis. Either USP5 (Falquet et al. 1995) or OTULIN can perform the proteolyic cleavage reactions (Grou et al. 2015).

Literature References
PubMed ID Title Journal Year
26235645 The de novo synthesis of ubiquitin: identification of deubiquitinases acting on ubiquitin precursors

Domingues, P, Grou, CP, Azevedo, JE, Pinto, MP, Mendes, AV

Sci Rep 2015
7851534 A human de-ubiquitinating enzyme with both isopeptidase and peptidase activities in vitro

Falquet, L, Jaton, JC, Hoang-Van, K, Paquet, N, Hughes, GJ, Frutiger, S

FEBS Lett. 1995
Participants
Participates
Catalyst Activity

thiol-dependent deubiquitinase activity of OTULIN,USP5 [cytosol]

Orthologous Events
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