OTULIN,USP5 cleaves UBB yielding ubiquitin

Stable Identifier
R-HSA-8853529
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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OTULIN,USP5 cleaves UBB yielding ubiquitin
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The UBB poly-protein contains 3 Ubiquitin monomers that are released by proteolysis. Either USP5 (Falquet et al. 1995) or OTULIN can perform the proteolyic cleavage reactions (Grou et al. 2015).
Literature References
PubMed ID Title Journal Year
26235645 The de novo synthesis of ubiquitin: identification of deubiquitinases acting on ubiquitin precursors

Domingues, P, Grou, CP, Azevedo, JE, Pinto, MP, Mendes, AV

Sci Rep 2015
7851534 A human de-ubiquitinating enzyme with both isopeptidase and peptidase activities in vitro

Falquet, L, Jaton, JC, Hoang-Van, K, Paquet, N, Hughes, GJ, Frutiger, S

FEBS Lett. 1995
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Output
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Catalyst Activity

cysteine-type deubiquitinase activity of OTULIN,USP5 [cytosol]

Physical Entity
OTULIN,USP5 [cytosol] (Homo sapiens)
Activity
cysteine-type deubiquitinase activity (GO:0004843)
Orthologous Events
OTULIN,USP5 cleaves UBB yielding ubiquitin (Bos taurus)
OTULIN,USP5 cleaves UBB yielding ubiquitin (Canis familiaris)
OTULIN,USP5 cleaves UBB yielding ubiquitin (Dictyostelium discoideum)
OTULIN,USP5 cleaves UBB yielding ubiquitin (Drosophila melanogaster)
OTULIN,USP5 cleaves UBB yielding ubiquitin (Mus musculus)
OTULIN,USP5 cleaves UBB yielding ubiquitin (Rattus norvegicus)
OTULIN,USP5 cleaves UBB yielding ubiquitin (Sus scrofa)
Authored
May, B  (2016-01-15)
Reviewed
Azevedo, JE  (2016-08-11)
Created
May, B  (2016-01-25)
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