UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin

Stable Identifier
R-HSA-8853514
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The UBA52 precursor protein contains the ribosomal protein L40 and ubiquitin (UBA52 residues 1 to 76) which are released by proteolysis. Any of the proteases UCHL3, USP7, or USP9X can catalyze the proteolysis reaction (Larsen et al. 1998, Grou et al. 2015).

Literature References
PubMed ID Title Journal Year
9521656 Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases

Wilkinson, KD, Larsen, CN, Krantz, BA

Biochemistry 1998
26235645 The de novo synthesis of ubiquitin: identification of deubiquitinases acting on ubiquitin precursors

Domingues, P, Grou, CP, Azevedo, JE, Pinto, MP, Mendes, AV

Sci Rep 2015
Participants
Participates
Catalyst Activity

cysteine-type deubiquitinase activity of UCHL3,USP7,USP9X [cytosol]

Orthologous Events
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