UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin

Stable Identifier
R-HSA-8853514
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin
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The UBA52 precursor protein contains the ribosomal protein L40 and ubiquitin (UBA52 residues 1 to 76) which are released by proteolysis. Any of the proteases UCHL3, USP7, or USP9X can catalyze the proteolysis reaction (Larsen et al. 1998, Grou et al. 2015).
Literature References
PubMed ID Title Journal Year
9521656 Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases

Larsen, CN, Krantz, BA, Wilkinson, KD

Biochemistry 1998
26235645 The de novo synthesis of ubiquitin: identification of deubiquitinases acting on ubiquitin precursors

Grou, CP, Pinto, MP, Mendes, AV, Domingues, P, Azevedo, JE

Sci Rep 2015
Participants
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Output
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as an event of
Catalyst Activity

cysteine-type deubiquitinase activity of UCHL3,USP7,USP9X [cytosol]

Physical Entity
UCHL3,USP7,USP9X [cytosol] (Homo sapiens)
Activity
cysteine-type deubiquitinase activity (GO:0004843)
Orthologous Events
UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Bos taurus)
UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Canis familiaris)
UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Danio rerio)
UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Dictyostelium discoideum)
UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Drosophila melanogaster)
UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Gallus gallus)
UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Mus musculus)
UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Plasmodium falciparum)
UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Rattus norvegicus)
UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Sus scrofa)
UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Xenopus tropicalis)
Authored
May, B  (2016-01-15)
Reviewed
Azevedo, JE  (2016-08-11)
Created
May, B  (2016-01-25)
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