Reactome | ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)

ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)

Stable Identifier

R-HSA-8853379

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)

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Two cytosolic deglycosylating systems can generate free oligosaccharides from glycoproteins; a deglycosylation complex that hydrolyses the whole glycan from an unfolded protein and cytosolic endo-beta-N-acetylglucosaminidase (ENGASE) that catalyses the endohydrolysis of -(Man(GlcNAc)2)Asn- structures in glycoproteins, leaving one N-acetyl-D-glucosamine (GlcNAc) residue attached to the protein (Suzuki et al. 2002). Glycans with a single GlcNAc at their reducing termini need to be further degraded by a cytosolic alpha-mannosidase, MAN2C1.

Literature References

PubMed ID	Title	Journal	Year
12114544	Endo-beta-N-acetylglucosaminidase, an enzyme involved in processing of free oligosaccharides in the cytosol Emori, Y, Kitajima, K, Inoue, Y, Sugimoto, S, Inoue, S, Yano, K, Suzuki, T, Lennarz, WJ	Proc. Natl. Acad. Sci. U.S.A.	2002