Reactome | ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)

ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)

Stable Identifier

R-HSA-8853379

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)

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Two cytosolic deglycosylating systems can generate free oligosaccharides from glycoproteins; a deglycosylation complex that hydrolyses the whole glycan from an unfolded protein and cytosolic endo-beta-N-acetylglucosaminidase (ENGASE) that catalyses the endohydrolysis of -(Man(GlcNAc)2)Asn- structures in glycoproteins, leaving one N-acetyl-D-glucosamine (GlcNAc) residue attached to the protein (Suzuki et al. 2002). Glycans with a single GlcNAc at their reducing termini need to be further degraded by a cytosolic alpha-mannosidase, MAN2C1.

Literature References

PubMed ID	Title	Journal	Year
12114544	Endo-beta-N-acetylglucosaminidase, an enzyme involved in processing of free oligosaccharides in the cytosol Suzuki, T, Yano, K, Sugimoto, S, Kitajima, K, Lennarz, WJ, Inoue, S, Inoue, Y, Emori, Y	Proc. Natl. Acad. Sci. U.S.A.	2002