MST1R autophosphorylates

Stable Identifier
R-HSA-8852552
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In response to ligand binding and receptor dimerisation, macrophage-stimulating protein receptor (MST1R aka RON) autophosphorylates on Tyr-1238 and Tyr-1239 in the kinase domain. This leads to further phosphorylation of Tyr-1353 and Tyr-1360 in the C-terminal multifunctional docking site (Yokoyama et al. 2005, Wang et al. 2010).

Literature References
PubMed ID Title Journal Year
20726546 The crystal structure of a constitutively active mutant RON kinase suggests an intramolecular autophosphorylation hypothesis

Wang, J, Steinbacher, S, Augustin, M, Schreiner, P, Epstein, D, Mulvihill, MJ, Crew, AP

Biochemistry 2010
15632155 The C terminus of RON tyrosine kinase plays an autoinhibitory role

Yokoyama, N, Ischenko, I, Hayman, MJ, Miller, WT

J. Biol. Chem. 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of MST1 dimer:2xMST1R dimer [plasma membrane]
Physical Entity
Activity
Orthologous Events
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