In response to ligand binding and receptor dimerisation, macrophage-stimulating protein receptor (MST1R aka RON) autophosphorylates on Tyr-1238 and Tyr-1239 in the kinase domain. This leads to further phosphorylation of Tyr-1353 and Tyr-1360 in the C-terminal multifunctional docking site (Yokoyama et al. 2005, Wang et al. 2010).
transmembrane receptor protein tyrosine kinase activity of MST1 dimer:2xMST1R dimer [plasma membrane]