Reactome | Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends

Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends

Stable Identifier

R-HSA-8852306

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends

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Starting in mitotic prometaphase, GTSE1 becomes phosphorylated at threonine residues T513 and T526 (and possibly other sites), located adjacent to the two SKIP-like motifs involved in binding to MAPRE1 (EB1). Mitotic phosphorylation of GTSE1 inhibits its association with microtubule plus ends. CDK1 activity inhibits the association of recombinant human GTSE1 with microtubule plus ends in Xenopus extracts, but it is not certain whether CDK1 or another mitotic kinase phosphorylates GTSE1 (Scolz et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
23236459	GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration Piazza, S, Hyman, AA, Scolz, M, Schneider, C, Bublik, DR, Peche, LY, Ellenberg, J, Widlund, PO, Hubner, N, Reber, S, Monte, M, Bird, AW, Ciani, Y, Isokane, M	PLoS ONE	2012