Reactome | UBA6 conjugates ubiquitin to cytosolic E2 enzymes

UBA6 conjugates ubiquitin to cytosolic E2 enzymes

Stable Identifier

R-HSA-8852127

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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UBA6 conjugates ubiquitin to cytosolic E2 enzymes

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In the cytosol, the UBA6-ubiquitin thiol ester conjugate transfers ubiquitin from UBA6 to an internal cysteine residue of the E2 enzyme, forming a thiol ester conjugate between ubiquitin and the cysteine residue of E2 (Jin et al. 2007, inferred from the rabbit homologue in Hershko et al. 1983, reviewed in Groettrup et al. 2008). As inferred from UBA1, the E2 then disengages from UBA6 (Eletr et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
17597759	Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging Jin, J, Li, X, Gygi, SP, Harper, JW	Nature	2007
18353650	Activating the ubiquitin family: UBA6 challenges the field Groettrup, M, Pelzer, C, Schmidtke, G, Hofmann, K	Trends Biochem. Sci.	2008
17580310	UBE1L2, a novel E1 enzyme specific for ubiquitin Pelzer, C, Kassner, I, Matentzoglu, K, Singh, RK, Wollscheid, HP, Scheffner, M, Schmidtke, G, Groettrup, M	J. Biol. Chem.	2007
16142244	E2 conjugating enzymes must disengage from their E1 enzymes before E3-dependent ubiquitin and ubiquitin-like transfer Eletr, ZM, Huang, DT, Duda, DM, Schulman, BA, Kuhlman, B	Nat. Struct. Mol. Biol.	2005