UBA6 conjugates ubiquitin to cytosolic E2 enzymes

Stable Identifier
Reaction [transition]
Homo sapiens
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In the cytosol, the UBA6-ubiquitin thiol ester conjugate transfers ubiquitin from UBA6 to an internal cysteine residue of the E2 enzyme, forming a thiol ester conjugate between ubiquitin and the cysteine residue of E2 (Jin et al. 2007, inferred from the rabbit homologue in Hershko et al. 1983, reviewed in Groettrup et al. 2008). As inferred from UBA1, the E2 then disengages from UBA6 (Eletr et al. 2005).

Literature References
PubMed ID Title Journal Year
17597759 Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging

Li, X, Gygi, SP, Jin, J, Harper, JW

Nature 2007
18353650 Activating the ubiquitin family: UBA6 challenges the field

Hofmann, K, Pelzer, C, Groettrup, M, Schmidtke, G

Trends Biochem. Sci. 2008
17580310 UBE1L2, a novel E1 enzyme specific for ubiquitin

Pelzer, C, Singh, RK, Groettrup, M, Scheffner, M, Matentzoglu, K, Schmidtke, G, Kassner, I, Wollscheid, HP

J. Biol. Chem. 2007
16142244 E2 conjugating enzymes must disengage from their E1 enzymes before E3-dependent ubiquitin and ubiquitin-like transfer

Huang, DT, Kuhlman, B, Duda, DM, Schulman, BA, Eletr, ZM

Nat. Struct. Mol. Biol. 2005
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