In the cytosol, the UBA6-ubiquitin thiol ester conjugate transfers ubiquitin from UBA6 to an internal cysteine residue of the E2 enzyme, forming a thiol ester conjugate between ubiquitin and the cysteine residue of E2 (Jin et al. 2007, inferred from the rabbit homologue in Hershko et al. 1983, reviewed in Groettrup et al. 2008). As inferred from UBA1, the E2 then disengages from UBA6 (Eletr et al. 2005).
Li, X, Gygi, SP, Jin, J, Harper, JW
Hofmann, K, Pelzer, C, Groettrup, M, Schmidtke, G
Pelzer, C, Singh, RK, Groettrup, M, Scheffner, M, Matentzoglu, K, Schmidtke, G, Kassner, I, Wollscheid, HP
Huang, DT, Kuhlman, B, Duda, DM, Schulman, BA, Eletr, ZM
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