MET phosphorylates GAB1

Stable Identifier
R-HSA-8851933
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MET phosphorylates GAB1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated MET phosphorylates GAB1 on at least five tyrosine residues: Y447, Y472, Y589, Y627 and Y659 (Schaeper et al. 2000, Chan et al. 2010).

Literature References
PubMed ID Title Journal Year
19881549 Differential phosphorylation of the docking protein Gab1 by c-Src and the hepatocyte growth factor receptor regulates different aspects of cell functions

Chan, PC, Sudhakar, JN, Lai, CC, Chen, HC

Oncogene 2010
10871282 Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

Schaeper, U, Gehring, NH, Fuchs, KP, Sachs, M, Kempkes, B, Birchmeier, W

J. Cell Biol. 2000
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of HGF:p-4Y-MET dimer:GAB1,HGF:p-4Y-MET dimer:GRB2:GAB1 [plasma membrane]
Physical Entity
HGF:p-4Y-MET dimer:GAB1,HGF:p-4Y-MET dimer:GRB2:GAB1 [plasma membrane]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
MET phosphorylates GAB1 (Caenorhabditis elegans)
MET phosphorylates GAB1 (Canis familiaris)
MET phosphorylates GAB1 (Danio rerio)
MET phosphorylates GAB1 (Gallus gallus)
MET phosphorylates GAB1 (Mus musculus)
MET phosphorylates GAB1 (Rattus norvegicus)
MET phosphorylates GAB1 (Sus scrofa)
MET phosphorylates GAB1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Heynen, G  (2016-07-11)
Birchmeier, W  (2016-07-11)
Created
Orlic-Milacic, M  (2016-01-12)