MET phosphorylates GAB1

Stable Identifier
R-HSA-8851933
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated MET phosphorylates GAB1 on at least five tyrosine residues: Y447, Y472, Y589, Y627 and Y659 (Schaeper et al. 2000, Chan et al. 2010).

Literature References
PubMed ID Title Journal Year
19881549 Differential phosphorylation of the docking protein Gab1 by c-Src and the hepatocyte growth factor receptor regulates different aspects of cell functions

Chan, PC, Sudhakar, JN, Lai, CC, Chen, HC

Oncogene 2010
10871282 Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

Schaeper, U, Gehring, NH, Fuchs, KP, Sachs, M, Kempkes, B, Birchmeier, W

J. Cell Biol. 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of HGF:p-4Y-MET dimer:GAB1,HGF:p-4Y-MET dimer:GRB2:GAB1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created