MET phosphorylates GAB1

Stable Identifier
R-HSA-8851933
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated MET phosphorylates GAB1 on at least five tyrosine residues: Y447, Y472, Y589, Y627 and Y659 (Schaeper et al. 2000, Chan et al. 2010).

Literature References
PubMed ID Title Journal Year
10871282 Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

Kempkes, B, Fuchs, KP, Birchmeier, W, Sachs, M, Gehring, NH, Schaeper, U

J. Cell Biol. 2000
19881549 Differential phosphorylation of the docking protein Gab1 by c-Src and the hepatocyte growth factor receptor regulates different aspects of cell functions

Chan, PC, Chen, HC, Lai, CC, Sudhakar, JN

Oncogene 2010
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of HGF:p-4Y-MET dimer:GAB1,HGF:p-4Y-MET dimer:GRB2:GAB1 [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!