Activated MET binds GAB1

Stable Identifier
R-HSA-8851908
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The adapter protein GAB1 can directly bind to phosphorylated MET receptor via its MET binding domain (MBD) (Schaeper et al. 2000, Lock et al. 2003).

Literature References
PubMed ID Title Journal Year
12766170 Grb2-independent recruitment of Gab1 requires the C-terminal lobe and structural integrity of the Met receptor kinase domain

Lock, LS, Frigault, MM, Saucier, C, Park, M

J Biol Chem 2003
10871282 Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

Schaeper, U, Gehring, NH, Fuchs, KP, Sachs, M, Kempkes, B, Birchmeier, W

J. Cell Biol. 2000
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created