SHC1-2 bound to MET recruits GRB2:SOS1

Stable Identifier
R-HSA-8851900
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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SHC1-2 bound to MET recruits GRB2:SOS1
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SHC1 splicing isoform 2 (SHC1-2) phosphorylated by MET on tyrosine residue Y317 recruits the GRB2:SOS1 complex to the activated MET receptor (Pelicci et al. 1995).

Literature References
PubMed ID Title Journal Year
7731718 The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein

Pelicci, G, Giordano, S, Zhen, Z, Salcini, AE, Lanfrancone, L, Bardelli, A, Panayotou, G, Waterfield, MD, Ponzetto, C, Pelicci, PG

Oncogene 1995
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
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SHC1-2 bound to MET recruits GRB2:SOS1 (Gallus gallus)
SHC1-2 bound to MET recruits GRB2:SOS1 (Mus musculus)
SHC1-2 bound to MET recruits GRB2:SOS1 (Rattus norvegicus)
SHC1-2 bound to MET recruits GRB2:SOS1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Heynen, G  (2016-07-11)
Birchmeier, W  (2016-07-11)
Created
Orlic-Milacic, M  (2016-01-12)