Reactome | CFHR1 [extracellular region]

CFHR1 [extracellular region]

Stable Identifier

R-HSA-8851432

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Complement factor H-related protein 1, FHR1_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Complement cascade (Homo sapiens)
    - Regulation of Complement cascade (Homo sapiens)
      - CFHR dimers bind C3b (Homo sapiens)
        
        CFHR dimers [extracellular region] (Homo sapiens)
        
        CFHR1 dimer [extracellular region] (Homo sapiens)
        
        CFHR1 [extracellular region] (Homo sapiens)
        
        Cell surface:C3b:CFHR dimers [plasma membrane] (Homo sapiens)
        
        CFHR dimers [extracellular region] (Homo sapiens)
        
        CFHR1 dimer [extracellular region] (Homo sapiens)
        
        CFHR1 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q03591 CFHR1

Gene Names

CFHR1, CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, HFL1, HFL2

Chain

signal peptide:1-18, chain:19-330

Reference Genes

BioGPS Gene:3078 CFHR1

COSMIC (genes):CFHR1 CFHR1

CTD Gene:3078 CFHR1

dbSNP Gene:3078 CFHR1

ENSEMBL:ENSG00000244414 CFHR1

ENSEMBL:ENSG00000244414.8 CFHR1

HGNC:4888 CFHR1

KEGG Gene (Homo sapiens):3078 CFHR1

Monarch:3078 CFHR1

NCBI Gene:3078 CFHR1

OMIM:134371 CFHR1

UCSC:Q03591 CFHR1

Reference Transcript

RefSeq:NM_002113.2 CFHR1

Other Identifiers

11743846_s_at

11757990_s_at

215388_PM_s_at

215388_s_at

2373394

2373396

2373398

2373399

2373426

2373427

2373429

2373430

2373431

2373432

2373433

2373434

2373435

2373436

2373437

2373438

2373439

2373495

2373496

2373498

2373499

2373500

2373514

3078

32249_at

36341_s_at

7908488

8180195

A_23_P114740

A_24_P336510

GO:0001851

GO:0002376

GO:0005515

GO:0005576

GO:0005615

GO:0006956

GO:0032091

GO:0032991

GO:0042802

GO:0051838

GO:0072562

GO:0098542

HMNXSV003042195

Hs.296941.0.S1_3p_s_at

ILMN_1754137

M65292_s_at

PH_hs_0038901

TC01006294.hg

Participates

as a component of

CFHR1 dimer [extracellular region] (Homo sapiens)

Inferred To

cfh [extracellular region] (Xenopus tropicalis)

svep1l [extracellular region] (Xenopus tropicalis)

Cfhr1 [extracellular region] (Mus musculus)

Cfhr1 [extracellular region] (Rattus norvegicus)

si:ch211-207o17.4 [extracellular region] (Danio rerio)

Homologues of CFHR1 [extracellular region] (Bos taurus)

Homologues of CFHR1 [extracellular region] (Canis familiaris)

Homologues of CFHR1 [extracellular region] (Danio rerio)

Homologues of CFHR1 [extracellular region] (Xenopus tropicalis)

LOC519737 [extracellular region] (Bos taurus)

f13b [extracellular region] (Xenopus tropicalis)

LOC100336868 [extracellular region] (Bos taurus)

CFH [extracellular region] (Bos taurus)

CFH [extracellular region] (Sus scrofa)

CFHR1 [extracellular region] (Canis familiaris)

CFHR1 [extracellular region] (Danio rerio)

CFHR1 [extracellular region] (Gallus gallus)

CFHR1 [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_002104.2

OpenTargets

ENSG00000244414

HPA

ENSG00000244414-CFHR1

GeneCards

Q03591

Ensembl

ENSP00000314299, ENSG00000244414, ENST00000320493

PRO

Q03591

Pharos - Targets

Q03591

Orphanet

20682

PDB

3ZD2, 4MUC

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08603 CFH	1	CFH [extracellular region] (R-HSA-976788)	0.636	3
UniProt:P01031 C5	7	C5(965-1676) [extracellular region] (R-HSA-8852713) C5aT [extracellular region] (R-HSA-8852711) C5a-desArg [extracellular region] (R-HSA-8852798) C5b alpha' [extracellular region] (R-HSA-173672) C5 alpha chain [extracellular region] (R-HSA-173673) C5 beta chain [extracellular region] (R-HSA-173675) C5a [extracellular region] (R-HSA-173677)	0.611	3

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