NTPDase4 (UDPase), encoded by the ENTPD4 gene, belongs to the E-NTPDase family of nucleotide phosphatases. NTPDase4 localizes to the Golgi membrane, with active site on the Golgi lumen side. In the presence of Ca2+, NTPDase4 hydrolyzes nucleoside diphosphates UDP, GDP, CDP and dTDP to nucleoside monophosphates UMP, GMP, CMP and dTMP, respectively (Wang and Guidotti 1998).
Wang, TF, Guidotti, G
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