NTPDase4 hydrolyzes nucleoside diphosphates

Stable Identifier
R-HSA-8851225
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi lumen, Golgi membrane
Synonyms
UDP + H2O => UMP + phosphate + H(+), CDP + H2O => CMP + phosphate + H(+), GDP + H2O => GMP + phosphate + H(+), dTDP + H2O => dTMP + phosphate + H(+)
ReviewStatus
5/5
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NTPDase4 hydrolyzes nucleoside diphosphates
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NTPDase4 (UDPase), encoded by the ENTPD4 gene, belongs to the E-NTPDase family of nucleotide phosphatases. NTPDase4 localizes to the Golgi membrane, with active site on the Golgi lumen side. In the presence of Ca2+, NTPDase4 hydrolyzes nucleoside diphosphates UDP, GDP, CDP and dTDP to nucleoside monophosphates UMP, GMP, CMP and dTMP, respectively (Wang and Guidotti 1998).
Literature References
PubMed ID Title Journal Year
9556635 Golgi localization and functional expression of human uridine diphosphatase

Wang, TF, Guidotti, G

J. Biol. Chem. 1998
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as an event of
Catalyst Activity

nucleoside diphosphate phosphatase activity of NTPDase4:Ca2+ [Golgi membrane]

Physical Entity
NTPDase4:Ca2+ [Golgi membrane] (Homo sapiens)
Activity
nucleoside diphosphate phosphatase activity (GO:0017110)
Orthologous Events
NTPDase4 hydrolyzes nucleoside diphosphates (Bos taurus)
NTPDase4 hydrolyzes nucleoside diphosphates (Caenorhabditis elegans)
NTPDase4 hydrolyzes nucleoside diphosphates (Canis familiaris)
NTPDase4 hydrolyzes nucleoside diphosphates (Gallus gallus)
NTPDase4 hydrolyzes nucleoside diphosphates (Mus musculus)
NTPDase4 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)
NTPDase4 hydrolyzes nucleoside diphosphates (Rattus norvegicus)
NTPDase4 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)
NTPDase4 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)
NTPDase4 hydrolyzes nucleoside diphosphates (Sus scrofa)
NTPDase4 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)
Cross References
RHEA
Authored
Orlic-Milacic, M  (2015-12-30)
Reviewed
Sévigny, J  (2016-05-11)
Created
Orlic-Milacic, M  (2016-01-06)
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