Casein kinase II phosphorylates PTEN

Stable Identifier
R-HSA-8850945
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Casein kinase II (CK2) constitutively phosphorylates the C-terminal tail of PTEN on serine and threonine residues S370, S380, T382, T383 and S385. S370 and S385 are the main CK2 phosphorylation sites in PTEN (Torres and Pulido 2001, Miller et al. 2002). CK2-mediated phosphorylation increases PTEN protein stability (Torres and Pulido 2001) but results in ~30% reduction in PTEN lipid phosphatase activity (Miller et al. 2002).

Literature References
PubMed ID Title Journal Year
12297295 Direct identification of PTEN phosphorylation sites

Miller, SJ, Lou, DY, Seldin, DC, Lane, WS, Neel, BG

FEBS Lett. 2002
11035045 The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

Torres, J, Pulido, R

J. Biol. Chem. 2001
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Catalyst Activity
Title
protein serine/threonine kinase activity of Casein kinase II [cytosol]
Physical Entity
Activity
Orthologous Events
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