Reactome | Casein kinase II phosphorylates PTEN

Casein kinase II phosphorylates PTEN

Stable Identifier

R-HSA-8850945

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Casein kinase II (CK2) constitutively phosphorylates the C-terminal tail of PTEN on serine and threonine residues S370, S380, T382, T383 and S385. S370 and S385 are the main CK2 phosphorylation sites in PTEN (Torres and Pulido 2001, Miller et al. 2002). CK2-mediated phosphorylation increases PTEN protein stability (Torres and Pulido 2001) but results in ~30% reduction in PTEN lipid phosphatase activity (Miller et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
11035045	The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation Torres, J, Pulido, R	J. Biol. Chem.	2001
12297295	Direct identification of PTEN phosphorylation sites Miller, SJ, Lou, DY, Seldin, DC, Lane, WS, Neel, BG	FEBS Lett.	2002