Reactome | NTPDase1 hydrolyzes nucleoside diphosphates

NTPDase1 hydrolyzes nucleoside diphosphates

Stable Identifier

R-HSA-8850854

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

Synonyms

a ribonucleoside 5'-diphosphate + H2O => a ribonucleoside 5'-phosphate + phosphate + H(+)

ReviewStatus

5/5

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NTPDase1 hydrolyzes nucleoside diphosphates

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NTPDase1 (CD39), a plasma membrane-bound nucleotide phosphatase encoded by the ENTPD1 gene, hydrolyzes extracellular NDPs to corresponding NMPs (Lemmens et al. 2000, Kukulski et al. 2005) which contributes to inhibition of platelet aggregation and thrombosis (Kaczmarek et al. 1996, Enjyoji et al. 1999, Marcus et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
8955160	Identification and characterization of CD39/vascular ATP diphosphohydrolase Kaczmarek, E, Koziak, K, Sévigny, J, Siegel, JB, Anrather, J, Beaudoin, AR, Bach, FH, Robson, SC	J Biol Chem	1996
18404504	Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8 Kukulski, F, Lévesque, SA, Lavoie, EG, Lecka, J, Bigonnesse, F, Knowles, AF, Robson, SC, Kirley, TL, Sévigny, J	Purinergic Signal.	2005
14675084	Heterologous cell-cell interactions: thromboregulation, cerebroprotection and cardioprotection by CD39 (NTPDase-1) Marcus, AJ, Broekman, MJ, Drosopoulos, JH, Islam, N, Pinsky, DJ, Sesti, C, Levi, R	J. Thromb. Haemost.	2003
10470077	Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation Enjyoji, K, Sévigny, J, Lin, Y, Frenette, PS, Christie, PD, Esch, JS, Imai, M, Edelberg, JM, Rayburn, H, Lech, M, Beeler, DL, Csizmadia, E, Wagner, DD, Robson, SC, Rosenberg, RD	Nat. Med.	1999
10866813	Distribution, cloning, and characterization of porcine nucleoside triphosphate diphosphohydrolase-1 Lemmens, R, Vanduffel, L, Kittel, A, Beaudoin, AR, Benrezzak, O, Sévigny, J	Eur. J. Biochem.	2000