NTPDase1 hydrolyzes nucleoside diphosphates

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
NTPDase1 (CD39), a plasma membrane-bound nucleotide phosphatase encoded by the ENTPD1 gene, hydrolyzes extracellular NDPs to corresponding NMPs (Lemmens et al. 2000, Kukulski et al. 2005) which contributes to inhibition of platelet aggregation and thrombosis (Kaczmarek et al. 1996, Enjyoji et al. 1999, Marcus et al. 2003).
Literature References
PubMed ID Title Journal Year
8955160 Identification and characterization of CD39/vascular ATP diphosphohydrolase

Anrather, J, Robson, SC, Sévigny, J, Beaudoin, AR, Siegel, JB, Koziak, K, Bach, FH, Kaczmarek, E

J Biol Chem 1996
18404504 Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8

Lavoie, EG, Lévesque, SA, Sévigny, J, Kukulski, F, Kirley, TL, Robson, SC, Bigonnesse, F, Lecka, J, Knowles, AF

Purinergic Signal. 2005
14675084 Heterologous cell-cell interactions: thromboregulation, cerebroprotection and cardioprotection by CD39 (NTPDase-1)

Broekman, MJ, Drosopoulos, JH, Pinsky, DJ, Islam, N, Marcus, AJ, Sesti, C, Levi, R

J. Thromb. Haemost. 2003
10470077 Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation

Lech, M, Frenette, PS, Csizmadia, E, Rosenberg, RD, Imai, M, Lin, Y, Enjyoji, K, Robson, SC, Wagner, DD, Sévigny, J, Edelberg, JM, Esch, JS, Christie, PD, Rayburn, H, Beeler, DL

Nat. Med. 1999
10866813 Distribution, cloning, and characterization of porcine nucleoside triphosphate diphosphohydrolase-1

Vanduffel, L, Beaudoin, AR, Benrezzak, O, Sévigny, J, Lemmens, R, Kittel, A

Eur. J. Biochem. 2000
Catalyst Activity

nucleoside-diphosphatase activity of NTPDase1:Ca2+,Mg2+ [plasma membrane]

Orthologous Events
Cross References
Cite Us!