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INPP5F [early endosome membrane]
Stable Identifier
R-HSA-8849952
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
early endosome membrane
Synonyms
Phosphatidylinositide phosphatase SAC2, SAC2_HUMAN, OCRL
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the early endosome membrane (Homo sapiens)
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Homo sapiens)
INPP5F [early endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y2H2 INPP5F
Gene Names
INPP5F, KIAA0966, SAC2, MSTP007, MSTP047
Chain
chain:1-1132
Reference Genes
BioGPS Gene:22876 INPP5F
COSMIC (genes):INPP5F INPP5F
CTD Gene:22876 INPP5F
dbSNP Gene:22876 INPP5F
ENSEMBL:ENSG00000198825 INPP5F
ENSEMBL_homo_sapiens_GENE:ENSG00000198825.15 INPP5F
HGNC:17054 INPP5F
KEGG Gene (Homo sapiens):22876 INPP5F
Monarch:22876 INPP5F
NCBI Gene:22876 INPP5F
OMIM:609389 INPP5F
UCSC:Q9Y2H2 INPP5F
Reference Transcript
RefSeq:NM_014937.3 INPP5F
RefSeq:NM_001243194.1 INPP5F
RefSeq:NM_001243195.1 INPP5F
Other Identifiers
11744526_a_at
11758025_x_at
16709865
203607_PM_at
203607_at
22876
230362_PM_at
230362_at
230363_PM_s_at
230363_s_at
3267383
3267384
3267385
3267386
3267388
3267389
3267390
3267391
3267392
3267393
3267395
3267397
3267399
3267400
3267403
3267404
3267405
3267406
3267410
3267411
3267412
3267413
3267414
3267415
3267416
3267418
3267420
3267421
3267423
3267424
3267425
3267426
3267448
36089_at
47043_at
50781_at
7930927
A_14_P106058
A_14_P123954
A_23_P35684
A_24_P4426
A_33_P3237096
A_33_P3238920
GE53628
GO:0001921
GO:0003012
GO:0003824
GO:0005515
GO:0005737
GO:0005768
GO:0005769
GO:0005886
GO:0005905
GO:0006629
GO:0006661
GO:0008344
GO:0008934
GO:0014898
GO:0016020
GO:0016192
GO:0016787
GO:0016791
GO:0023052
GO:0030154
GO:0030424
GO:0030425
GO:0031161
GO:0031410
GO:0031901
GO:0033137
GO:0034595
GO:0034596
GO:0036211
GO:0042532
GO:0042803
GO:0043025
GO:0043226
GO:0043231
GO:0043491
GO:0043812
GO:0045334
GO:0046856
GO:0048015
GO:0048681
GO:0048856
GO:0048870
GO:0051896
GO:0052832
GO:0052833
GO:0052834
GO:0055037
GO:0072583
GO:2000145
GO:2001135
HMNXSV003040043
HMNXSV003040743
HMNXSV003056069
Hs.52463.1.S1_3p_a_at
ILMN_1779917
ILMN_1811718
ILMN_1813650
PH_hs_0003533
TC10000869.hg
TC10002326.hg
TC10002327.hg
g7662413_3p_at
Inferred To
INPP5F [early endosome membrane]
(Bos taurus)
INPP5F [early endosome membrane]
(Canis familiaris)
INPP5F [early endosome membrane]
(Dictyostelium discoideum)
INPP5F [early endosome membrane]
(Gallus gallus)
INPP5F [early endosome membrane]
(Plasmodium falciparum)
INPP5F [early endosome membrane]
(Sus scrofa)
sp3 [early endosome membrane]
(Drosophila melanogaster)
sac1 [early endosome membrane]
(Dictyostelium discoideum)
inpp5f [early endosome membrane]
(Danio rerio)
inpp5f [early endosome membrane]
(Xenopus tropicalis)
sac-2 [early endosome membrane]
(Caenorhabditis elegans)
Homologues of INPP5F [early endosome membrane]
(Dictyostelium discoideum)
Inpp5f [early endosome membrane]
(Mus musculus)
Inpp5f [early endosome membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_001230123.1
,
NP_001230124.1
,
NP_055752.1
OpenTargets
ENSG00000198825
GeneCards
Q9Y2H2
HPA
ENSG00000198825-INPP5F
Ensembl
ENSP00000489864
,
ENST00000650623
,
ENST00000650409
,
ENSG00000198825
,
ENSP00000497527
,
ENSP00000496955
,
ENST00000369081
PRO
Q9Y2H2
Pharos - Targets
Q9Y2H2
PDB
4XUU
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.569
4
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.569
3
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