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RGS3 [plasma membrane]
Stable Identifier
R-HSA-8849410
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Regulator of G-protein signaling 3, RGS3_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Active G alpha (i)–i1/i2/i3 binds RGS proteins (Homo sapiens)
G alpha (i):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Homo sapiens)
G alpha (i):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Homo sapiens)
G alpha (i):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
G alpha (i):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Active G alpha (q) binds RGS proteins (Homo sapiens)
G alpha (q):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
RGS proteins active for G alpha (q) [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
G alpha (q) in G (q):RGS complex is inactivated (Homo sapiens)
G alpha (q):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
G alpha (q):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
G alpha (q):RGS dissociates to inactive G alpha (q) (Homo sapiens)
G alpha (q):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49796 RGS3
Gene Names
RGS3
Chain
chain:1-1198
Reference Genes
BioGPS Gene:5998 RGS3
COSMIC (genes):RGS3 RGS3
CTD Gene:5998 RGS3
dbSNP Gene:5998 RGS3
ENSEMBL:ENSG00000138835 RGS3
HGNC:9999 RGS3
KEGG:hsa:5998 RGS3
Monarch:5998 RGS3
NCBI Gene:5998 RGS3
OMIM:602189 RGS3
UCSC:P49796 RGS3
Reference Transcript
RefSeq:NM_144488.8 RGS3
RefSeq:XM_006717226.2 RGS3
RefSeq:XM_011518897.2 RGS3
RefSeq:NM_134427.2 RGS3
RefSeq:XM_011518900.1 RGS3
RefSeq:NM_001282922.2 RGS3
RefSeq:NM_130795.4 RGS3
RefSeq:NM_001276261.2 RGS3
RefSeq:NM_017790.4 RGS3
RefSeq:NM_144489.3 RGS3
RefSeq:XM_017015005.1 RGS3
RefSeq:NM_001351526.2 RGS3
RefSeq:XM_006717219.2 RGS3
RefSeq:NM_001276262.1 RGS3
RefSeq:XM_011518898.1 RGS3
RefSeq:XM_017015006.1 RGS3
RefSeq:NM_001282923.1 RGS3
RefSeq:NM_001276260.2 RGS3
RefSeq:XM_011518901.1 RGS3
RefSeq:XM_006717230.3 RGS3
RefSeq:XM_011518896.1 RGS3
Participates
as a member of
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS proteins active for G alpha (q) [plasma membrane] (Homo sapiens)
Inferred To
RGS3 [plasma membrane]
(Bos taurus)
RGS3 [plasma membrane]
(Canis familiaris)
Rgs3 [plasma membrane]
(Mus musculus)
Rgs3 [plasma membrane]
(Rattus norvegicus)
PsGEF [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_570613.2
,
NP_652760.2
,
XP_011517199.1
,
NP_001263190.1
,
NP_001263191.1
,
NP_001269851.1
,
NP_602299.1
,
XP_016870494.1
,
NP_060260.3
,
NP_001263189.1
,
NP_001269852.1
,
XP_006717282.1
,
XP_006717293.1
,
XP_011517200.1
,
XP_011517198.1
,
XP_011517202.1
,
NP_001338455.1
,
XP_006717289.1
,
XP_016870495.1
,
XP_011517203.1
,
NP_652759.4
Guide to Pharmacology - Targets
2810
OpenTargets
ENSG00000138835
ENSEMBL
ENST00000374140
,
ENST00000462143
,
ENST00000343817
,
ENSP00000378141
,
ENST00000317613
,
ENST00000374134
,
ENSP00000363249
,
ENSG00000138835
,
ENST00000350696
,
ENST00000394646
,
ENSP00000420356
,
ENSP00000259406
,
ENSP00000312844
,
ENSP00000340284
,
ENSP00000363255
HPA
ENSG00000138835-RGS3
GeneCards
RGS3
PRO
P49796
Pharos - Targets
P49796
GlyGen
P49796
PDB
2OJ4
,
2F5Y
,
3FBK
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q07065 CKAP4
7
CKAP4 [endoplasmic reticulum lumen]
(R-HSA-8956737)
p-CKAP4 [endoplasmic reticulum lumen]
(R-HSA-8956926)
CKAP4 [specific granule membrane]
(R-HSA-6799552)
CKAP4 [plasma membrane]
(R-HSA-5686306)
CKAP4 [azurophil granule membrane]
(R-HSA-6799559)
PALM-C100-CKAP4 [plasma membrane]
(R-HSA-5686280)
PALM-C100-CKAP4 [lamellar body]
(R-HSA-5686285)
0.527
4
UniProt:Q9BZF9 UACA
1
UACA [cytosol]
(R-HSA-6804636)
0.527
3
UniProt:Q15019 SEPTIN2
1
SEPT2 [cytosol]
(R-HSA-5626657)
0.527
3
UniProt:P43155 CRAT
2
CRAT [cytosol]
(R-HSA-9033096)
CRAT [peroxisomal matrix]
(R-HSA-390293)
0.527
4
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.527
2
UniProt:Q7Z3C6 ATG9A
1
ATG9A [phagophore assembly site membrane]
(R-HSA-5671732)
0.527
4
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