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RGS3 [plasma membrane]
Stable Identifier
R-HSA-8849410
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Regulator of G-protein signaling 3, RGS3_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Active G alpha (i)–i1/i2/i3 binds RGS proteins (Homo sapiens)
G alpha (i):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Homo sapiens)
G alpha (i):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Homo sapiens)
G alpha (i):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
G alpha (i):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Active G alpha (q) binds RGS proteins (Homo sapiens)
G alpha (q):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
RGS proteins active for G alpha (q) [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
G alpha (q) in G (q):RGS complex is inactivated (Homo sapiens)
G alpha (q):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
G alpha (q):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
G alpha (q):RGS dissociates to inactive G alpha (q) (Homo sapiens)
G alpha (q):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49796 RGS3
Gene Names
RGS3
Chain
chain:1-1198
Reference Genes
BioGPS Gene:5998 RGS3
COSMIC (genes):RGS3 RGS3
CTD Gene:5998 RGS3
dbSNP Gene:5998 RGS3
ENSEMBL:ENSG00000138835 RGS3
HGNC:9999 RGS3
KEGG:hsa:5998 RGS3
Monarch:5998 RGS3
NCBI Gene:5998 RGS3
OMIM:602189 RGS3
UCSC:P49796 RGS3
Reference Transcript
RefSeq:NM_001276262.1 RGS3
RefSeq:NM_001282922.1 RGS3
RefSeq:NM_001282923.1 RGS3
RefSeq:XM_011518900.1 RGS3
RefSeq:XM_006717230.3 RGS3
RefSeq:XM_011518896.1 RGS3
RefSeq:XM_011518901.1 RGS3
RefSeq:XM_006717219.2 RGS3
RefSeq:XM_011518897.2 RGS3
RefSeq:NM_001276260.1 RGS3
RefSeq:NM_017790.4 RGS3
RefSeq:NM_001276261.1 RGS3
RefSeq:NM_134427.2 RGS3
RefSeq:XM_006717226.2 RGS3
RefSeq:NM_144488.5 RGS3
RefSeq:XM_017015005.1 RGS3
RefSeq:NM_144489.3 RGS3
RefSeq:NM_130795.3 RGS3
RefSeq:XM_017015006.1 RGS3
RefSeq:XM_011518898.1 RGS3
Other Identifiers
11740106_a_at
11750154_a_at
11758050_s_at
11760984_a_at
17088230
203823_PM_at
203823_at
220300_PM_at
220300_at
3185644
3185647
3185650
3185651
3185652
3185656
3185657
3185658
3185665
3185666
3185669
3185670
3185672
3185673
3185675
3185684
3185685
3185686
3185687
3185688
3185689
3185691
3185692
3185693
3185694
3185695
3185698
3185700
3185701
3185702
3185703
3185704
3185705
3185707
3185709
3185710
3185711
3185715
3185718
3185723
3185724
3185725
3185726
3185727
3185731
3185732
3185733
3185734
3185749
3185757
3185758
3185759
3185760
3185761
3185762
3185763
3185764
3185765
3185766
3185767
3185768
3185771
3185772
3185773
3185774
3185775
3185776
3185777
3185778
3185779
3185780
3185781
3185782
3185783
3185784
3185785
3185786
37637_at
5998
71969_at
79795_at
8157324
AF006609_at
A_14_P128034
A_23_P219197
A_24_P377775
GE55469
GE59043
GO:0003824
GO:0003924
GO:0005096
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0007186
GO:0008277
GO:0009968
GO:0016787
GO:0030695
GO:0043226
GO:0098772
HMNXSV003033573
HMNXSV003045190
ILMN_1724349
ILMN_1728711
ILMN_1731478
ILMN_1763371
ILMN_2248655
ILMN_2260224
PH_hs_0004711
U27655_at
g10864074_3p_at
g8923347_3p_at
Participates
as a member of
RGS proteins active for G alpha (q) [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
Inferred To
RGS3 [plasma membrane]
(Bos taurus)
RGS3 [plasma membrane]
(Canis familiaris)
Rgs3 [plasma membrane]
(Mus musculus)
Rgs3 [plasma membrane]
(Rattus norvegicus)
PsGEF [plasma membrane]
(Drosophila melanogaster)
Cross References
Guide to Pharmacology - Targets
2810
OpenTargets
ENSG00000138835
ENSEMBL
ENST00000374140
,
ENST00000462143
,
ENST00000350696
,
ENST00000317613
,
ENSP00000363249
,
ENST00000394646
,
ENSP00000312844
,
ENSP00000420356
,
ENSP00000378141
,
ENSP00000363255
,
ENSP00000259406
,
ENST00000374134
,
ENST00000343817
,
ENSP00000340284
HPA
ENSG00000138835-RGS3
PRO
P49796
Pharos - Targets
P49796
GlyGen
P49796
PDB
2OJ4
,
3FBK
,
2F5Y
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.527
2
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