Phosphorylated KHDRBS1 translocates to the cytosol

Stable Identifier
R-HSA-8848993
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
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Phosphorylated KHDRBS1 translocates to the cytosol
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PTK6 (BRK) mediated phosphorylation of nuclear localization signal (NLS) of the RNA binding protein KHDRBS1 (SAM68) results in nuclear exclusion of KHDRBS1 and interferes with the antiproliferative role of KHDRBS1 (Lukong et al. 2005).

Literature References
PubMed ID Title Journal Year
16179349 Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression

Lukong, KE, Larocque, D, Tyner, AL, Richard, S

J. Biol. Chem. 2005
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Orthologous Events
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Phosphorylated KHDRBS1 translocates to the cytosol (Drosophila melanogaster)
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Phosphorylated KHDRBS1 translocates to the cytosol (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-01-05)
Reviewed
Pires, IM  (2016-02-07)
Created
Orlic-Milacic, M  (2015-12-11)