Reactome | AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM

AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM

Stable Identifier

R-HSA-8848585

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM

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AWAT2 (Acyl-CoA wax alcohol acyltransferase 2, also known as MFAT and DC4) associated with the endoplasmic reticulum membrane catalyzes the reaction of atROL (all-trans retinol) and PALM-CoA (palmitoyl-CoA) to form the ester retinyl palmitate. This ester is thought to provide an inactive storage form of retinol and might play a role in protecting skin, where AWAT2 is most abundant from the effects of UV light (Arne et al. 2017; Yen et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
16106050	A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters Brown, CH, Farese, RV, Monetti, M, Yen, CL	J. Lipid Res.	2005
28096191	Allosteric modulation of the substrate specificity of acyl-CoA wax alcohol acyltransferase 2 (AWAT2) Hughes, T, Huynh, KW, Golczak, M, Chelstowska, S, Silvaroli, JA, Widjaja-Adhi, MA, Moiseenkova-Bell, VY, Arne, JM	J. Lipid Res.	2017