AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM

Stable Identifier
R-HSA-8848585
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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AWAT2 (Acyl-CoA wax alcohol acyltransferase 2, also known as MFAT and DC4) associated with the endoplasmic reticulum membrane catalyzes the reaction of atROL (all-trans retinol) and PALM-CoA (palmitoyl-CoA) to form the ester retinyl palmitate. This ester is thought to provide an inactive storage form of retinol and might play a role in protecting skin, where AWAT2 is most abundant from the effects of UV light (Arne et al. 2017; Yen et al. 2005).

Literature References
PubMed ID Title Journal Year
28096191 Allosteric modulation of the substrate specificity of acyl-CoA wax alcohol acyltransferase 2 (AWAT2)

Arne, JM, Widjaja-Adhi, MA, Hughes, T, Huynh, KW, Silvaroli, JA, Chelstowska, S, Moiseenkova-Bell, VY, Golczak, M

J. Lipid Res. 2017
16106050 A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters

Yen, CL, Brown, CH, Monetti, M, Farese, RV

J. Lipid Res. 2005
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
retinol O-fatty-acyltransferase activity of AWAT2 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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