AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester

Stable Identifier
Reaction [transition]
Homo sapiens
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AWAT2 (Acyl-CoA wax alcohol acyltransferase 2, also known as MFAT and DC4) associated with the endoplasmic reticulum membrane catalyzes the reaction of HXOL (hexadecanol) and PALM-CoA (palmitoyl-CoA) to form the wax monoester palmityl palmitate. The enzyme also acts efficiently on other long-chain fatty alcohols and fatty acyl CoAs. It is abundant in skin and is thought to play a central role in the synthesis of wax molecules that protect the skin from drying (Cheng & Russell 2004; Turkish et al. 2005; Yen et al. 2005).

Literature References
PubMed ID Title Journal Year
15220349 Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family

Cheng, JB, Russell, DW

J. Biol. Chem. 2004
16106050 A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters

Brown, CH, Farese, RV, Monetti, M, Yen, CL

J. Lipid Res. 2005
15671038 Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily

Bazzi, H, Billheimer, JT, Cromley, D, Turkish, AR, Sturley, SL, Oelkers, P, Henneberry, AL, Padamsee, M, Christiano, AM

J. Biol. Chem. 2005
Catalyst Activity

long-chain-alcohol O-fatty-acyltransferase activity of AWAT2 [endoplasmic reticulum membrane]

Orthologous Events
Cross References
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