Reactome | AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester

AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester

Stable Identifier

R-HSA-8848582

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

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AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester

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AWAT2 (Acyl-CoA wax alcohol acyltransferase 2, also known as MFAT and DC4) associated with the endoplasmic reticulum membrane catalyzes the reaction of HXOL (hexadecanol) and PALM-CoA (palmitoyl-CoA) to form the wax monoester palmityl palmitate. The enzyme also acts efficiently on other long-chain fatty alcohols and fatty acyl CoAs. It is abundant in skin and is thought to play a central role in the synthesis of wax molecules that protect the skin from drying (Cheng & Russell 2004; Turkish et al. 2005; Yen et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
16106050	A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters Yen, CL, Brown, CH, Monetti, M, Farese, RV	J. Lipid Res.	2005
15220349	Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family Cheng, JB, Russell, DW	J. Biol. Chem.	2004
15671038	Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily Turkish, AR, Henneberry, AL, Cromley, D, Padamsee, M, Oelkers, P, Bazzi, H, Christiano, AM, Billheimer, JT, Sturley, SL	J. Biol. Chem.	2005