AWAT2 (Acyl-CoA wax alcohol acyltransferase 2, also known as MFAT and DC4) associated with the endoplasmic reticulum membrane catalyzes the reaction of HXOL (hexadecanol) and PALM-CoA (palmitoyl-CoA) to form the wax monoester palmityl palmitate. The enzyme also acts efficiently on other long-chain fatty alcohols and fatty acyl CoAs. It is abundant in skin and is thought to play a central role in the synthesis of wax molecules that protect the skin from drying (Cheng & Russell 2004; Turkish et al. 2005; Yen et al. 2005).
Cheng, JB, Russell, DW
Brown, CH, Farese, RV, Monetti, M, Yen, CL
Bazzi, H, Billheimer, JT, Cromley, D, Turkish, AR, Sturley, SL, Oelkers, P, Henneberry, AL, Padamsee, M, Christiano, AM
long-chain-alcohol O-fatty-acyltransferase activity of AWAT2 [endoplasmic reticulum membrane]
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