AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester

Stable Identifier
R-HSA-8848582
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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AWAT2 (Acyl-CoA wax alcohol acyltransferase 2, also known as MFAT and DC4) associated with the endoplasmic reticulum membrane catalyzes the reaction of HXOL (hexadecanol) and PALM-CoA (palmitoyl-CoA) to form the wax monoester palmityl palmitate. The enzyme also acts efficiently on other long-chain fatty alcohols and fatty acyl CoAs. It is abundant in skin and is thought to play a central role in the synthesis of wax molecules that protect the skin from drying (Cheng & Russell 2004; Turkish et al. 2005; Yen et al. 2005).

Literature References
PubMed ID Title Journal Year
16106050 A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters

Yen, CL, Brown, CH, Monetti, M, Farese, RV

J. Lipid Res. 2005
15220349 Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family

Cheng, JB, Russell, DW

J. Biol. Chem. 2004
15671038 Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily

Turkish, AR, Henneberry, AL, Cromley, D, Padamsee, M, Oelkers, P, Bazzi, H, Christiano, AM, Billheimer, JT, Sturley, SL

J. Biol. Chem. 2005
Participants
Participates
Catalyst Activity

long-chain-alcohol O-fatty-acyltransferase activity of AWAT2 [endoplasmic reticulum membrane]

Orthologous Events
Cross References
Rhea
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