Three human enzymes can utilise ketone bodies for energy production. Two mitochondrial enzymes function in ketolysis whereas a cytosolic enzyme is implicated in cytosolic cholesterol biosynthesis. Cytosolic acetyl-CoA acetyltransferase tetramer (ACAT2 tetramer) (Song et al. 1994) catalyses the condensation of two acetyl-CoA (Ac-CoA) molecules to form acetoacetyl-CoA (ACA-CoA). This is the first step in the biosynthesis of cholesterol (Fukao et al. 1997).
Sukegawa, K, Orii, T, Mitchell, GA, Kondo, N, Yamaguchi, S, Fukao, T, Song, XQ
Hashimoto, T, Orii, T, Yamaguchi, S, Fukao, T, Miyazawa, S, Song, XQ
acetyl-CoA C-acetyltransferase activity of ACAT2 tetramer [cytosol]
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