Three human enzymes can utilise ketone bodies for energy production. Two mitochondrial enzymes function in ketolysis whereas a cytosolic enzyme is implicated in cytosolic cholesterol biosynthesis. Cytosolic acetyl-CoA acetyltransferase tetramer (ACAT2 tetramer) (Song et al. 1994) catalyses the condensation of two acetyl-CoA (Ac-CoA) molecules to form acetoacetyl-CoA (ACA-CoA). This is the first step in the biosynthesis of cholesterol (Fukao et al. 1997).
Song, XQ, Fukao, T, Yamaguchi, S, Miyazawa, S, Hashimoto, T, Orii, T
Fukao, T, Song, XQ, Mitchell, GA, Yamaguchi, S, Sukegawa, K, Orii, T, Kondo, N
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