Reactome | ACAT2 condenses 2 Ac-CoA to form ACA-CoA

ACAT2 condenses 2 Ac-CoA to form ACA-CoA

Stable Identifier

R-HSA-8848215

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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ACAT2 condenses 2 Ac-CoA to form ACA-CoA

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Three human enzymes can utilise ketone bodies for energy production. Two mitochondrial enzymes function in ketolysis whereas a cytosolic enzyme is implicated in cytosolic cholesterol biosynthesis. Cytosolic acetyl-CoA acetyltransferase tetramer (ACAT2 tetramer) (Song et al. 1994) catalyses the condensation of two acetyl-CoA (Ac-CoA) molecules to form acetoacetyl-CoA (ACA-CoA). This is the first step in the biosynthesis of cholesterol (Fukao et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
7911016	Molecular cloning and nucleotide sequence of complementary DNA for human hepatic cytosolic acetoacetyl-coenzyme A thiolase Song, XQ, Fukao, T, Yamaguchi, S, Miyazawa, S, Hashimoto, T, Orii, T	Biochem. Biophys. Res. Commun.	1994
9380443	Enzymes of ketone body utilization in human tissues: protein and messenger RNA levels of succinyl-coenzyme A (CoA):3-ketoacid CoA transferase and mitochondrial and cytosolic acetoacetyl-CoA thiolases Fukao, T, Song, XQ, Mitchell, GA, Yamaguchi, S, Sukegawa, K, Orii, T, Kondo, N	Pediatr. Res.	1997