Reactome | ACAT2 condenses 2 Ac-CoA to form ACA-CoA

ACAT2 condenses 2 Ac-CoA to form ACA-CoA

Stable Identifier

R-HSA-8848215

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

2 acetyl-CoA => acetoacetyl-CoA + CoA

ReviewStatus

5/5

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ACAT2 condenses 2 Ac-CoA to form ACA-CoA

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Three human enzymes, two mitochondrial and one cytosolic, catalyze the interconversion of acetyl-CoA and acetoacetyl-CoA. The cytosolic form, acetyl-CoA acetyltransferase tetramer (ACAT2 tetramer) (Song et al. 1994), catalyses the condensation of two acetyl-CoA (Ac-CoA) molecules to form acetoacetyl-CoA (ACA-CoA). This is the first step in the biosynthesis of cholesterol (Fukao et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
9380443	Enzymes of ketone body utilization in human tissues: protein and messenger RNA levels of succinyl-coenzyme A (CoA):3-ketoacid CoA transferase and mitochondrial and cytosolic acetoacetyl-CoA thiolases Fukao, T, Song, XQ, Mitchell, GA, Yamaguchi, S, Sukegawa, K, Orii, T, Kondo, N	Pediatr. Res.	1997
7911016	Molecular cloning and nucleotide sequence of complementary DNA for human hepatic cytosolic acetoacetyl-coenzyme A thiolase Song, XQ, Fukao, T, Yamaguchi, S, Miyazawa, S, Hashimoto, T, Orii, T	Biochem. Biophys. Res. Commun.	1994