FRK phosphorylates PTEN

Stable Identifier
R-HSA-8847977
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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FRK phosphorylates PTEN
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FRK tyrosine kinase (RAK) phosphorylates PTEN on tyrosine residue Y336. FRK-mediated phosphorylation inhibits NEDD4-mediated polyubiquitination and subsequent degradation of PTEN, thus increasing PTEN half-life. FRK-mediated phosphorylation also increases PTEN enzymatic activity (Yim et al. 2009).
Literature References
PubMed ID Title Journal Year
19345329 Rak functions as a tumor suppressor by regulating PTEN protein stability and function

Li, K, Dai, H, Lu, Y, Hu, R, Craven, RJ, Hennessy, BT, Meric-Bernstam, F, Mills, GB, Yim, EK, Lin, SY, Peng, G

Cancer Cell 2009
Participants
Input
Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of PTEN:p-Y387-FRK [cytosol]

Physical Entity
PTEN:p-Y387-FRK [cytosol] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
FRK phosphorylates PTEN (Bos taurus)
FRK phosphorylates PTEN (Caenorhabditis elegans)
FRK phosphorylates PTEN (Canis familiaris)
FRK phosphorylates PTEN (Drosophila melanogaster)
FRK phosphorylates PTEN (Gallus gallus)
FRK phosphorylates PTEN (Mus musculus)
FRK phosphorylates PTEN (Rattus norvegicus)
FRK phosphorylates PTEN (Sus scrofa)
FRK phosphorylates PTEN (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-12-03)
Reviewed
Salmena, L  (2016-08-11)
Leslie, N  (2016-09-30)
Kriplani, N  (2016-09-30)
Carracedo, A  (2016-08-11)
Created
Orlic-Milacic, M  (2015-12-03)
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