FRK phosphorylates PTEN

Stable Identifier
R-HSA-8847977
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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FRK tyrosine kinase (RAK) phosphorylates PTEN on tyrosine residue Y336. FRK-mediated phosphorylation inhibits NEDD4-mediated polyubiquitination and subsequent degradation of PTEN, thus increasing PTEN half-life. FRK-mediated phosphorylation also increases PTEN enzymatic activity (Yim et al. 2009).

Literature References
PubMed ID Title Journal Year
19345329 Rak functions as a tumor suppressor by regulating PTEN protein stability and function

Yim, EK, Peng, G, Dai, H, Hu, R, Li, K, Lu, Y, Mills, GB, Meric-Bernstam, F, Hennessy, BT, Craven, RJ, Lin, SY

Cancer Cell 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of PTEN:p-Y387-FRK [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created