PTEN binds FRK

Stable Identifier
R-HSA-8847968
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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General
SVG |   | PPTX  | SBGN
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FRK (RAK), a SRC family member kinase, binds PTEN. The interaction involves the SH3 domain of FRK and the C2 domain of PTEN (Yim et al. 2009). Like other SRC family members, FRK is autophosphorylated on a C-terminal tyrosine residue Y387. FRK possesses a nuclear localization signal and is found in both nucleus and the cytosol (Cance et al. 1994).

Literature References
PubMed ID Title Journal Year
19345329 Rak functions as a tumor suppressor by regulating PTEN protein stability and function

Yim, EK, Peng, G, Dai, H, Hu, R, Li, K, Lu, Y, Mills, GB, Meric-Bernstam, F, Hennessy, BT, Craven, RJ, Lin, SY

Cancer Cell 2009
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created