JAK2 phosphorylates STAT5; phosphorylated STAT5 dimerizes and translocates to the nucleus (Darnell et al., 1994), binds DNA and activates target genes including c-fos, pim-1, oncostatin M, and Id-1 (Mui et al. 1996). STAT5 activation is believed to be the primary signaling mechanism for Bc (Ihle, 2001).
Flores-Morales, A, Pircher, TJ, Gustafsson, JA, Norstedt, G, Haldosén, LA, Wood, TJ, Silvennoinen, O, Sanchez-Gomez, M
protein tyrosine kinase activity of High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane]
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