Activation of STAT5a/b by JAK2

Stable Identifier
R-HSA-879909
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Activation of STAT5a/b by JAK2
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JAK2 phosphorylates STAT5; phosphorylated STAT5 dimerizes and translocates to the nucleus (Darnell et al., 1994), binds DNA and activates target genes including c-fos, pim-1, oncostatin M, and Id-1 (Mui et al. 1996). STAT5 activation is believed to be the primary signaling mechanism for Bc (Ihle, 2001).

Literature References
PubMed ID Title Journal Year
9685210 In vitro interaction between STAT 5 and JAK 2; dependence upon phosphorylation status of STAT 5 and JAK 2

Flores-Morales, A, Pircher, TJ, Silvennoinen, O, Gustafsson, JA, Sanchez-Gomez, M, Norstedt, G, Haldosén, LA, Wood, TJ

Mol Cell Endocrinol 1998
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane]
Physical Entity
High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
Activation of STAT5a/b by JAK2 (Bos taurus)
Activation of STAT5a/b by JAK2 (Canis familiaris)
Activation of STAT5a/b by JAK2 (Danio rerio)
Activation of STAT5a/b by JAK2 (Mus musculus)
Activation of STAT5a/b by JAK2 (Rattus norvegicus)
Authored
Ray, KP  (2010-05-17)
Reviewed
Lopez, AF  (2010-09-06)
Hercus, TR  (2010-09-06)
Created
Jupe, S  (2010-06-25)