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P2X7 forms oligomeric non-selective cation channels
Stable Identifier
R-HSA-877158
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
Inflammasomes (Homo sapiens)
The NLRP3 inflammasome (Homo sapiens)
P2X7 forms oligomeric non-selective cation channels (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
At low to intermediate concentrations of extracellular ATP, P2X4 and P2X7 probably function as heterotrimeric, reversible ATP-gated, non-desensitizing cation channels (Markwardt 2007).
Participants
Input
x 3
ATP:P2X7 [plasma membrane]
(Homo sapiens)
Output
ATP:P2X7 oligomer [plasma membrane]
(Homo sapiens)
Participates
as an event of
The NLRP3 inflammasome (Homo sapiens)
Inferred From
p2x7 forms oligomeric non-selective cation channels (Rattus norvegicus)
Authored
Jupe, S (2010-04-22)
Reviewed
Kufer, TA (2011-04-28)
Rittinger, K (2011-06-06)
Wong, E (2011-06-06)
Created
Jupe, S (2010-06-11)
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