Reactome | Release of STAT1 dimer from active receptor unit

Release of STAT1 dimer from active receptor unit

Stable Identifier

R-HSA-873927

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Release of STAT1 dimer from active receptor unit

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The phosphorylated STAT1 on IFNGR1 chains homodimerize through reciprocal SH2-phosphotyrosine interactions to form p-STAT1 homodimer called gamma-activated-factor (GAF). This phosphorylated STAT1 homodimer disassociates from the receptor complex and translocates to the nucleus.

Literature References

PubMed ID	Title	Journal	Year
18591661	Tyrosine phosphorylation regulates the partitioning of STAT1 between different dimer conformations Wenta, N, Strauss, H, Meyer, S, Vinkemeier, U	Proc Natl Acad Sci U S A	2008
12915721	The ins and outs of STAT1 nuclear transport McBride, KM, Reich, NC	Sci STKE	2003
7510216	Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions Shuai, K, Horvath, CM, Huang, LH, Qureshi, SA, Cowburn, D, Darnell JE, Jr	Cell	1994