Phosphorylation of IFNGR1 by JAK kinases

Stable Identifier
R-HSA-873924
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The phosphorylated active JAK1 kinase inturn phosphorylates tyrosine residue 440 on each of the IFNGR1 chains to form two adjacent docking sites for the latent STAT1 SH2 domains.

Literature References
PubMed ID Title Journal Year
16237089 Signaling through a mutant IFN-gamma receptor

Heinrich, PC, Arulampalam, V, Watling, D, Is'harc, H, Newman, SJ, Kerr, IM, Hermanns, HM, Costa-Pereira, AP, Williams, TM

J Immunol 2005
7514165 Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor

Wilks, AF, Finbloom, DS, Ziemiecki, A, Ozmen, L, Harpur, AG, Garotta, G, Larner, AC, Igarashi, K

J Biol Chem 1994
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!