Phosphorylation of IFNGR1 by JAK kinases

Stable Identifier
R-HSA-873924
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The phosphorylated active JAK1 kinase inturn phosphorylates tyrosine residue 440 on each of the IFNGR1 chains to form two adjacent docking sites for the latent STAT1 SH2 domains.

Literature References
PubMed ID Title Journal Year
7514165 Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor

Igarashi, K, Garotta, G, Ozmen, L, Ziemiecki, A, Wilks, AF, Harpur, AG, Larner, AC, Finbloom, DS

J Biol Chem 1994
16237089 Signaling through a mutant IFN-gamma receptor

Costa-Pereira, AP, Hermanns, HM, Is'harc, H, Williams, TM, Watling, D, Arulampalam, V, Newman, SJ, Heinrich, PC, Kerr, IM

J Immunol 2005
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane]

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