Reactome | Phosphorylation of IFNGR1 by JAK kinases

Phosphorylation of IFNGR1 by JAK kinases

Stable Identifier

R-HSA-873924

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Phosphorylation of IFNGR1 by JAK kinases

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The phosphorylated active JAK1 kinase inturn phosphorylates tyrosine residue 440 on each of the IFNGR1 chains to form two adjacent docking sites for the latent STAT1 SH2 domains.

Literature References

PubMed ID	Title	Journal	Year
16237089	Signaling through a mutant IFN-gamma receptor Costa-Pereira, AP, Hermanns, HM, Is'harc, H, Williams, TM, Watling, D, Arulampalam, V, Newman, SJ, Heinrich, PC, Kerr, IM	J Immunol	2005
7514165	Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor Igarashi, K, Garotta, G, Ozmen, L, Ziemiecki, A, Wilks, AF, Harpur, AG, Larner, AC, Finbloom, DS	J Biol Chem	1994