The phosphorylated active JAK1 kinase inturn phosphorylates tyrosine residue 440 on each of the IFNGR1 chains to form two adjacent docking sites for the latent STAT1 SH2 domains.
Heinrich, PC, Arulampalam, V, Watling, D, Is'harc, H, Newman, SJ, Kerr, IM, Hermanns, HM, Costa-Pereira, AP, Williams, TM
Wilks, AF, Finbloom, DS, Ziemiecki, A, Ozmen, L, Harpur, AG, Garotta, G, Larner, AC, Igarashi, K
protein tyrosine kinase activity of IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane]
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