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Beta oxidation of myristoyl-CoA to lauroyl-CoA
Stable Identifier
R-HSA-77285
Type
Pathway
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Mitochondrial Fatty Acid Beta-Oxidation (Homo sapiens)
mitochondrial fatty acid beta-oxidation of saturated fatty acids (Homo sapiens)
Beta oxidation of myristoyl-CoA to lauroyl-CoA (Homo sapiens)
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The second pass through the beta-oxidation spiral starts with the saturated fatty acid myristoyl-CoA (from the first swing through the beta oxidation spiral) and produces lauroyl-CoA. Four enzymatic steps are required starting with LCAD CoA dehydrogenase (Long Chain) activity, followed by three enzymatic steps, enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and ketoacyl-CoA thiolase activities, all present in the mitochondrial membrane associated trifunctional protein.
Literature References
PubMed ID
Title
Journal
Year
The Metabolic and Molecular Bases of Inherited Disease, 8th ed
Beaudet, AL
,
Scriver, CR
,
Sly, WS
,
Valle, D
2001
Participants
Events
myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2
(Homo sapiens)
trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA
(Homo sapiens)
(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H
(Homo sapiens)
3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA
(Homo sapiens)
Participates
as an event of
mitochondrial fatty acid beta-oxidation of saturated fatty acids (Homo sapiens)
Event Information
Go Biological Process
fatty acid beta-oxidation (0006635)
Orthologous Events
Beta oxidation of myristoyl-CoA to lauroyl-CoA (Bos taurus)
Beta oxidation of myristoyl-CoA to lauroyl-CoA (Caenorhabditis elegans)
Beta oxidation of myristoyl-CoA to lauroyl-CoA (Canis familiaris)
Beta oxidation of myristoyl-CoA to lauroyl-CoA (Danio rerio)
Beta oxidation of myristoyl-CoA to lauroyl-CoA (Drosophila melanogaster)
Beta oxidation of myristoyl-CoA to lauroyl-CoA (Gallus gallus)
Beta oxidation of myristoyl-CoA to lauroyl-CoA (Mus musculus)
Beta oxidation of myristoyl-CoA to lauroyl-CoA (Rattus norvegicus)
Beta oxidation of myristoyl-CoA to lauroyl-CoA (Sus scrofa)
Beta oxidation of myristoyl-CoA to lauroyl-CoA (Xenopus tropicalis)
Authored
Gillespie, ME (2003-09-19)
Created
Gillespie, ME (2003-09-19)
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