1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]

Stable Identifier
R-HSA-75900
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
Synonyms
Conversion of Diacylglycerol to Triacylglycerol [DGAT1]
ReviewStatus
5/5
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1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]
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Tetrameric diacylglycerol O-acyltransferase 1 (DGAT1) associated with the endoplasmic reticulum membrane catalyzes the reaction of 1,2-diacyl-glycerol and acyl-CoA to form triacylglycerol + CoASH (Cheng et al. 2001).
Literature References
PubMed ID Title Journal Year
11672446 Human acyl-CoA:diacylglycerol acyltransferase is a tetrameric protein

Billheimer, JT, Cromley, DA, Cheng, D, Young, PR, He, B, Meegalla, RL

Biochem J 2001
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Output
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as an event of
Catalyst Activity

diacylglycerol O-acyltransferase activity of DGAT1 tetramer [endoplasmic reticulum membrane]

Physical Entity
DGAT1 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
Activity
diacylglycerol O-acyltransferase activity (GO:0004144)
Orthologous Events
1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Bos taurus)
1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Caenorhabditis elegans)
1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Canis familiaris)
1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Danio rerio)
1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Dictyostelium discoideum)
1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Drosophila melanogaster)
1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Mus musculus)
1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Plasmodium falciparum)
1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Rattus norvegicus)
1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Sus scrofa)
1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Xenopus tropicalis)
Created
Gopinathrao, G  (2003-09-07)
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