glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]

Stable Identifier
Reaction [transition]
Homo sapiens
Conversion of glycerol-3-phosphate to lysophosphatidic acid
Locations in the PathwayBrowser
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Either of GPAM or GPAT2 (glycerol-3-phosphate acyltransferase, mitochondrial; glycerol-3-phosphate acyltransferase 2, mitochondrial) associated with the outer mitochondrial membrane catalyzes the reaction of cytosolic glycerol 3-phosphate and acyl-CoA to form 1-acylglycerol 3-phosphate and CoASH. The biochemical properties and location of human GPAM have been established through studies of the recombinant protein (Chen et al. 2008); those features of GPAT2 have been inferred from the properties of its rat homologue and those of GPAM. GPAM and GPAT2 differ in their their preferences for acyl-CoA substrates (Shindou & Shimizu 2009) and in their expression patterns in the body (Takeuchi & Reue 2009).
Literature References
PubMed ID Title Journal Year
18238778 AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase

Kuo, MS, Qian, YW, Li, S, Bredt, DS, Chu, S, Beigneux, AP, Bui, HH, Sanders, PE, Thibodeaux, SJ, Zhao, Y, Cao, G, Chen, YQ, Moller, DE, Peake, DA, Young, SG, Konrad, RJ

J Biol Chem 2008
19336658 Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis

Reue, K, Takeuchi, K

Am J Physiol Endocrinol Metab 2009
18718904 Acyl-CoA:lysophospholipid acyltransferases

Shindou, H, Shimizu, T

J Biol Chem 2009
Catalyst Activity

glycerol-3-phosphate O-acyltransferase activity of GPAM or GPAT2 [mitochondrial outer membrane]

Orthologous Events
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