glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]

Stable Identifier
R-HSA-75886
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, mitochondrial outer membrane
Synonyms
Conversion of glycerol-3-phosphate to lysophosphatidic acid
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Either of GPAM or GPAT2 (glycerol-3-phosphate acyltransferase, mitochondrial; glycerol-3-phosphate acyltransferase 2, mitochondrial) associated with the outer mitochondrial membrane catalyzes the reaction of cytosolic glycerol 3-phosphate and acyl-CoA to form 1-acylglycerol 3-phosphate and CoASH. The biochemical properties and location of human GPAM have been established through studies of the recombinant protein (Chen et al. 2008); those features of GPAT2 have been inferred from the properties of its rat homologue and those of GPAM. GPAM and GPAT2 differ in their their preferences for acyl-CoA substrates (Shindou & Shimizu 2009) and in their expression patterns in the body (Takeuchi & Reue 2009).
Literature References
PubMed ID Title Journal Year
18238778 AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase

Kuo, MS, Qian, YW, Li, S, Bredt, DS, Chu, S, Beigneux, AP, Bui, HH, Sanders, PE, Thibodeaux, SJ, Zhao, Y, Cao, G, Chen, YQ, Moller, DE, Peake, DA, Young, SG, Konrad, RJ

J Biol Chem 2008
19336658 Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis

Reue, K, Takeuchi, K

Am J Physiol Endocrinol Metab 2009
18718904 Acyl-CoA:lysophospholipid acyltransferases

Shindou, H, Shimizu, T

J Biol Chem 2009
Participants
Input
Output
Participates
as an event of
Catalyst Activity

glycerol-3-phosphate O-acyltransferase activity of GPAM or GPAT2 [mitochondrial outer membrane]

Physical Entity
GPAM or GPAT2 [mitochondrial outer membrane] (Homo sapiens)
Activity
glycerol-3-phosphate O-acyltransferase activity (GO:0004366)
Orthologous Events
glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Bos taurus)
glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Caenorhabditis elegans)
glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Canis familiaris)
glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Drosophila melanogaster)
glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Gallus gallus)
glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Mus musculus)
glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Rattus norvegicus)
glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Sus scrofa)
glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Xenopus tropicalis)
Authored
Gopinathrao, G  (2003-10-02)
Created
Gopinathrao, G  (2003-09-07)
Cite Us!