Reactome | 1-acyl LPA is acylated to PA by AGPAT (LPAAT)

1-acyl LPA is acylated to PA by AGPAT (LPAAT)

Stable Identifier

R-HSA-75885

Type

Reaction

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, lysophosphatidic acid + fatty acyl CoA => phosphatidic acid + CoA (1)

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Summation

At the endoplasmic reticulum (ER) membrane, 1-acyl-lysophosphatidic acid (LPA) is acylated to phosphatidic acid (PA) by the enzymes 1-acyl-sn-glycerol-3-phosphate acyltransferases (AGPAT1 through 11), and lysophosphatidylcholine acyltransferase (LPCAT1) (Aguado and Campbell 1998).

See recent review by Agarwal (2012, in press).

AGPAT1, 2, 3 and LPCAT1 have been characterized biochemically (AGPAT1, 2: Yamashita et al. 2007, West et al. 1997, Aguado and Campbell 1998, Gale et al. 2006; AGPAT3: Agarwal et al. 2006; LPCAT1: Nakanishi et al. 2006, Chen et al. 2006). Two additional proteins, AGPAT4 and AGPAT5, are inferred to have such activity based on studies of homologous mouse enzymes (Lu et al. 2005). These enzymes differ in their tissue specific patterns of expression in the body and in their preferences for specific acyl CoA molecules (Shindou and Shimizu 2009; Takeuchi and Reue 2009).

Literature References

PubMed ID	Title	Journal	Year
16704971	Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production Nakanishi, H, Shindou, H, Hishikawa, D, Harayama, T, Ogasawara, R, Suwabe, A, Taguchi, R, Shimizu, T	J Biol Chem	2006
9212163	Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells West, J, Tompkins, CK, Balantac, N, Nudelman, E, Meengs, B, White, T, Bursten, S, Coleman, J, Kumar, A, Singer, JW, Leung, DW	DNA Cell Biol	1997
9461603	Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex Aguado, B, Campbell, RD	J Biol Chem	1998
15367102	Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart Lu, B, Jiang, YJ, Zhou, Y, Xu, FY, Hatch, GM, Choy, PC	Biochem J	2005
16620771	Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity Agarwal, AK, Barnes, RI, Garg, A	Arch Biochem Biophys	2006
22777291	Lysophospholipid acyltransferases: 1-acylglycerol-3-phosphate O-acyltransferases. From discovery to disease Agarwal, AK	Curr. Opin. Lipidol.	2012
16864775	Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells Chen, X, Hyatt, BA, Mucenski, ML, Mason, RJ, Shannon, JM	Proc Natl Acad Sci U S A	2006
17707131	Topology of acyltransferase motifs and substrate specificity and accessibility in 1-acyl-sn-glycero-3-phosphate acyltransferase 1 Yamashita, A, Nakanishi, H, Suzuki, H, Kamata, R, Tanaka, K, Waku, K, Sugiura, T	Biochim Biophys Acta	2007
19336658	Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis Takeuchi, K, Reue, K	Am J Physiol Endocrinol Metab	2009
16495223	A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation Gale, SE, Frolov, A, Han, X, Bickel, PE, Cao, L, Bowcock, A, Schaffer, JE, Ory, DS	J Biol Chem	2006
18718904	Acyl-CoA:lysophospholipid acyltransferases Shindou, H, Shimizu, T	J Biol Chem	2009