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Relocalization of nuclearly localized Cyclin D1 to the cytoplasm
Stable Identifier
R-HSA-75823
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nuclear envelope
ReviewStatus
5/5
Locations in the PathwayBrowser
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Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
S Phase (Homo sapiens)
Ubiquitin-dependent degradation of Cyclin D (Homo sapiens)
Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In this reaction, 1 molecule of 'phospho(T286)-Cyclin D1' is translocated from nucleoplasm to cytosol.
This reaction takes place in the 'nuclear envelope' (Diehl et al. 1997).
Literature References
PubMed ID
Title
Journal
Year
9372967
A dominant-negative cyclin D1 mutant prevents nuclear import of cyclin-dependent kinase 4 (CDK4) and its phosphorylation by CDK-activating kinase
Diehl, JA
,
Sherr, CJ
Mol. Cell. Biol.
1997
Participants
Input
p-T286-CCND1 [nucleoplasm]
(Homo sapiens)
Output
p-T286-CCND1 [cytosol]
(Homo sapiens)
Participates
as an event of
Ubiquitin-dependent degradation of Cyclin D (Homo sapiens)
Orthologous Events
Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Bos taurus)
Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Caenorhabditis elegans)
Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Canis familiaris)
Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Danio rerio)
Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Drosophila melanogaster)
Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Gallus gallus)
Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Mus musculus)
Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Rattus norvegicus)
Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Schizosaccharomyces pombe)
Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Sus scrofa)
Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Xenopus tropicalis)
Created
Matthews, L (2003-09-01)
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