Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box

Stable Identifier
R-HSA-74992
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

PTRF binds the quaternary complex and mediates the dissociation of paused complex. PTRF interacts with the RNA polymerase I largest subunit (p194), TTF-I and the U-rich 3' end of the nascent pre-rRNA.

Literature References
PubMed ID Title Journal Year
9582279 Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes.

Jansa, P, Mason, SW, Hoffmann-Rohrer, U, Grummt, I

EMBO J 1998
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