CYLD deubiquitinates NEMO

Stable Identifier
R-HSA-741411
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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CYLD deubiquitinates NEMO
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RIP2-induced ubiquitination of NEMO and consequent NFkappaB activation can be reversed in a dose-responsive manner by the deubiquitinase CYLD, suggesting that CYLD negatively regulates RIP2-induced NEMO ubiquitinylation.
Literature References
PubMed ID Title Journal Year
12917691 The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

Kovalenko, A, Chable-Bessia, C, Cantarella, G, Israel, A, Wallach, D, Courtois, G

Nature 2003
15620648 The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO

Abbott, DW, Wilkins, A, Asara, JM, Cantley, LC

Curr Biol 2004
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Catalyst Activity

K63-linked deubiquitinase activity of CYLD [cytosol]

Physical Entity
CYLD [cytosol] (Homo sapiens)
Activity
K63-linked deubiquitinase activity (GO:0061578)
Orthologous Events
CYLD deubiquitinates NEMO (Bos taurus)
CYLD deubiquitinates NEMO (Canis familiaris)
CYLD deubiquitinates NEMO (Danio rerio)
CYLD deubiquitinates NEMO (Mus musculus)
CYLD deubiquitinates NEMO (Rattus norvegicus)
Authored
Jupe, S  (2010-04-22)
Reviewed
Kufer, TA  (2011-04-28)
Rittinger, K  (2011-06-06)
Wong, E  (2011-06-06)
Created
Jupe, S  (2010-05-14)
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