RIP2 induces K63-linked ubiquitination of NEMO

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R-HSA-741386
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Reaction [transition]
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Homo sapiens
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RIP2 induces the K63-linked ubiquitination of NEMO at K285 and K399, positively modulating subsequent NF-kappaB activation (Abbot et al. 2007). TRAF6 E3 ligase is capable of performing this ubiquitination step when overexpressed in HEK239 cells, and this effect is blocked if RIP2 siRNA is co-transfected, but small interfering RNA (siRNA) experiments indicate that there are additional E3 ligases that can substitute for TRAF6 in NEMO ubiquitination. In addition to TRAF6, the K63-specific E2 ligase Ubc13 is required for NEMO ubiquitination suggesting a common mechanism for NEMO ubiquitination in NOD and TLR signaling.

Literature References
PubMed ID Title Journal Year
17562858 Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains

Abbott, DW, Yang, Y, Hutti, JE, Madhavarapu, S, Kelliher, MA, Cantley, LC

Mol Cell Biol 2007
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Title
ubiquitin-protein transferase activity of TRAF6 E3/E2 ubiquitin ligase complex [cytosol]
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Orthologous Events
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