Reactome | Abortive initiation after formation of the first phosphodiester bond

Abortive initiation after formation of the first phosphodiester bond

Stable Identifier

R-HSA-73946

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Abortive initiation after formation of the first phosphodiester bond

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At the beginning of this reaction, 1 molecule of 'pol II transcription complex' is present. At the end of this reaction, 1 molecule of 'TFIIA', 1 molecule of 'TFIIH', 1 molecule of 'TFIIE', 1 molecule of 'TFIID', 1 molecule of 'TFIIB', 1 molecule of 'RNA Polymerase II (unphosphorylated):TFIIF complex', and 1 molecule of 'template DNA with first transcript dinucleotide, opened to +8 position' are present.

This reaction takes place in the 'nucleus'.

Literature References

PubMed ID	Title	Journal	Year
1939271	Abortive initiation is increased only for the weakest members of a set of down mutants of the adenovirus 2 major late promoter. Luse, SW, Jacob, GA, Luse, DS	J Biol Chem	1991