The reversible synthesis of inosine 5'-monophosphate from 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) is catalyzed by the IMP cyclohydrolase activity of the bifunctional 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase enzyme. This cytosolic protein occurs primarily as a dimer (Rayl et al. 1996; Vergis et al. 2001) and may further associate with other enzymes of de novo IMP biosynthesis under some metabolic conditions (An et al. 2008).
Benkovic, SJ, Sheets, ED, Kumar, R, An, S
Beardsley, GP, Vergis, JM, Bulock, KG, Fleming, KG
Beardsley, GP, Rayl, EA, Moroson, BA
IMP cyclohydrolase activity of ATIC dimer [cytosol]
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