Formation of SL1

Stable Identifier
R-HSA-73729
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Formation of SL1
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Human SL1 is a four subunit complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs): TAF(1)110, TAF(1)63, and TAF(1)48. Note that none of these three TAFs for Pol I show any homology to the Pol II or Pol III TAFs. TAFs SL1 is a species specific factor.
Literature References
PubMed ID Title Journal Year
7801123 Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits.

Comai, L, Zomerdijk, JC, Beckmann, H, Zhou, S, Tjian, R

Science 1995
2805069 Molecular mechanisms governing species-specific transcription of ribosomal RNA.

Bell, SP, Pikaard, CS, Reeder, RH, Tjian, R

Cell 1989
17318177 A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription

Gorski, JJ, Pathak, S, Panov, K, Kasciukovic, T, Panova, T, Russell, J, Zomerdijk, JC

EMBO J. 2007
1547496 The TATA-binding protein and associated factors are integral components of the RNA polymerase I transcription factor, SL1.

Comai, L, Tanese, N, Tjian, R

Cell 1992
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Orthologous Events
Formation of SL1 (Bos taurus)
Formation of SL1 (Canis familiaris)
Formation of SL1 (Mus musculus)
Formation of SL1 (Rattus norvegicus)
Created
Comai, L  (2003-07-03)
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