Reactome | TYMS [cytosol]

TYMS [cytosol]

Stable Identifier

R-HSA-73518

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Thymidylate synthase , TS, TSase

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - G1/S-Specific Transcription (Homo sapiens)
        
        TYMS gene expression (Homo sapiens)
        
        TYMS [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P04818 TYMS

Gene Names

TYMS, TS, OK/SW-cl.29

Chain

initiator methionine:1, chain:2-313

Reference Genes

BioGPS Gene:7298 TYMS

COSMIC - genes:TYMS TYMS

CTD Gene:7298 TYMS

dbSNP Gene:7298 TYMS

ENSEMBL:ENSG00000176890 TYMS

HGNC:12441 TYMS

KEGG:hsa:7298 TYMS

Monarch:7298 TYMS

NCBI Gene:7298 TYMS

OMIM:188350 TYMS

UCSC:P04818 TYMS

Reference Transcript

Other Identifiers

11718058_a_at

11751805_a_at

1505_at

1554696_PM_s_at

1554696_s_at

16850477

202589_PM_at

202589_at

217684_PM_at

217684_at

3775843

3775844

3775845

3775846

3775847

3775848

3775849

3775850

3775851

3775853

3775855

3775856

3775857

3775858

3775859

3775860

3775861

3775862

3775864

3775865

3775866

3775867

3775868

3775870

3775872

3775874

37899_at

7298

8019842

A_23_P50096

D00596_at

GE59639

GO:0000900

GO:0004146

GO:0004799

GO:0005542

GO:0005634

GO:0005737

GO:0005739

GO:0005743

GO:0005759

GO:0005829

GO:0006231

GO:0006235

GO:0006575

GO:0006730

GO:0008168

GO:0009165

GO:0016020

GO:0016491

GO:0016740

GO:0016741

GO:0017148

GO:0032259

GO:0035999

GO:0045182

GO:0046653

GO:0055086

GO:0071897

GO:1901135

GO:1990825

HMNXSV003037502

Hs.141307.0.S1_3p_at

Hs2.432651.1.S1_3p_s_at

ILMN_1806040

PH_hs_0022201

TC18000006.hg

g4507750_3p_at

Participates

as an output of

TYMS gene expression (Homo sapiens)

as a component of

TS dimer [cytosol] (Homo sapiens)

Inferred To

TYMS [cytosol] (Bos taurus)

TYMS [cytosol] (Canis familiaris)

TYMS [cytosol] (Drosophila melanogaster)

TYMS [cytosol] (Gallus gallus)

TYMS [cytosol] (Mus musculus)

TYMS [cytosol] (Plasmodium falciparum)

TYMS [cytosol] (Rattus norvegicus)

TYMS [cytosol] (Saccharomyces cerevisiae)

TYMS [cytosol] (Schizosaccharomyces pombe)

TYMS [cytosol] (Sus scrofa)

tyms [cytosol] (Danio rerio)

tyms [cytosol] (Xenopus tropicalis)

tyms-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001062.1, NP_001341796.1, NP_001341797.1

ZINC - World Drugs

TYSY_HUMAN

Guide to Pharmacology - Targets

2642

OpenTargets

ENSG00000176890

ENSEMBL

ENSP00000314727, ENSP00000314902, ENST00000323274, ENST00000323224, ENSG00000176890, ENSP00000315644, ENST00000323250

ZINC - FDA approved

TYSY_HUMAN

ZINC - Substances

TYSY_HUMAN

ZINC - Biogenic

TYSY_HUMAN

ZINC target

P04818

PRO

P04818

GlyGen

P04818

PDB

3EDW, 6QXH, 5X5Q, 4JEF, 1HVY, 6PF5, 6R2E, 6QXG, 3EGY, 3ED7, 3HB8, 4O1U, 3EHI, 3H9K, 3N5G, 1JU6, 5WRN, 4UP1, 4GD7, 1YPV, 3EBU, 3GH0, 1HZW, 6ZXO, 3EJL, 6QYQ, 5X4W, 3OB7, 2RDA, 3GH2, 5X4Y, 3EF9, 6PF6, 1I00, 4G6W, 6PF4, 5X5A, 1JUJ, 6PF3, 6OJU, 6OJV, 4E28, 4GYH, 3N5E, 5X66, 4FGT, 3GG5, 2RD8, 2ONB, 5X69, 4H1I, 5X67, 4O1X, 1HW4, 1HW3, 4G2O, 5X5D, 5X4X, 3EAW, 4KPW, 5HS3

ZINC - Investigational

TYSY_HUMAN

ZINC - Metabolites

TYSY_HUMAN

IntEnz

2.1.1.45

HPA

ENSG00000176890-TYMS

GeneCards

TYMS

Pharos - Targets

P04818

Orphanet

TYMS

ZINC - Predictions - Purchasable

TYSY_HUMAN

HMDB Protein

HMDBP04363

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P48059 LIMS1	1	LIMS1 [cytosol] (R-HSA-432859)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q9Y2B9 IPKG			0.527	2
UniProt:O60925 PFDN1	1	PFDN1 [cytosol] (R-HSA-379541)	0.527	2