SLC29A3 transports nucleosides from cytosol to lysosomal lumen

Stable Identifier
R-HSA-727767
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Equilibrative transport (import) of nucleosides and adenine by solute carrier family 29 (nucleoside transporters), member 3
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The human gene SLC29A3 encodes the equilibrative nucleoside transporter 3 (ENT3). It is abundant in many tissues, especially the placenta and is localized intracellularly on the lysosomal membrane. SLC29A3 mediates the reversible transport of nucleosides and the nucleobase adenine (Baldwin et al. 2005). Defects in SLC29A3 can cause histiocytosis-lymphadenopathy plus syndrome (HLAS; MIM:602782), an autosomal recessive disorder characterised by combined features from 2 or more of four histiocytic disorders (Molho-Pessach et al. 2008).

Literature References
PubMed ID Title Journal Year
15701636 Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes

Baldwin, SA, Yao, SY, Hyde, RJ, Ng, AM, Foppolo, S, Barnes, K, Ritzel, MW, Cass, CE, Young, JD

J Biol Chem 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
nucleoside transmembrane transporter activity of SLC29A3 [lysosomal membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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