Reactome | SLC29A3 transports nucleosides from cytosol to lysosomal lumen

SLC29A3 transports nucleosides from cytosol to lysosomal lumen

Stable Identifier

R-HSA-727767

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, lysosomal membrane, lysosomal lumen

Synonyms

Equilibrative transport (import) of nucleosides and adenine by solute carrier family 29 (nucleoside transporters), member 3

ReviewStatus

5/5

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SLC29A3 transports nucleosides from cytosol to lysosomal lumen

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The human gene SLC29A3 encodes the equilibrative nucleoside transporter 3 (ENT3). It is abundant in many tissues, especially the placenta and is localized intracellularly on the lysosomal membrane. SLC29A3 mediates the reversible transport of nucleosides and the nucleobase adenine (Baldwin et al. 2005). Defects in SLC29A3 can cause histiocytosis-lymphadenopathy plus syndrome (HLAS; MIM:602782), an autosomal recessive disorder characterised by combined features from 2 or more of four histiocytic disorders (Molho-Pessach et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
15701636	Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes Ritzel, MW, Foppolo, S, Hyde, RJ, Ng, AM, Barnes, K, Baldwin, SA, Young, JD, Cass, CE, Yao, SY	J Biol Chem	2005