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Release of 40S and 60S subunits from the 80S ribosome
Stable Identifier
R-HSA-72673
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Formation of a pool of free 40S subunits (Homo sapiens)
Release of 40S and 60S subunits from the 80S ribosome (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
80S monosomes dissociate into 40S and 60S ribosomal subunits. eIF1A promotes this dissociation.
Participants
Input
80S ribosome [cytosol]
(Homo sapiens)
EIF1AX [cytosol]
(Homo sapiens)
Output
40S ribosomal complex [cytosol]
(Homo sapiens)
60S ribosomal complex [cytosol]
(Homo sapiens)
EIF1AX [cytosol]
(Homo sapiens)
Participates
as an event of
Formation of a pool of free 40S subunits (Homo sapiens)
Orthologous Events
Release of 40S and 60S subunits from the 80S ribosome (Bos taurus)
Release of 40S and 60S subunits from the 80S ribosome (Caenorhabditis elegans)
Release of 40S and 60S subunits from the 80S ribosome (Canis familiaris)
Release of 40S and 60S subunits from the 80S ribosome (Danio rerio)
Release of 40S and 60S subunits from the 80S ribosome (Dictyostelium discoideum)
Release of 40S and 60S subunits from the 80S ribosome (Drosophila melanogaster)
Release of 40S and 60S subunits from the 80S ribosome (Gallus gallus)
Release of 40S and 60S subunits from the 80S ribosome (Mus musculus)
Release of 40S and 60S subunits from the 80S ribosome (Plasmodium falciparum)
Release of 40S and 60S subunits from the 80S ribosome (Rattus norvegicus)
Release of 40S and 60S subunits from the 80S ribosome (Saccharomyces cerevisiae)
Release of 40S and 60S subunits from the 80S ribosome (Schizosaccharomyces pombe)
Release of 40S and 60S subunits from the 80S ribosome (Sus scrofa)
Release of 40S and 60S subunits from the 80S ribosome (Xenopus tropicalis)
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