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EIF5B [cytosol]
Stable Identifier
R-HSA-72501
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF5B, translation initiation factor 5B
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
The 60S subunit joins the translation initiation complex (Homo sapiens)
80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Homo sapiens)
eIF5B:GTP [cytosol] (Homo sapiens)
EIF5B [cytosol] (Homo sapiens)
eIF5B:GTP [cytosol] (Homo sapiens)
EIF5B [cytosol] (Homo sapiens)
eIF5B:GTP is hydrolyzed and released (Homo sapiens)
80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Homo sapiens)
eIF5B:GTP [cytosol] (Homo sapiens)
EIF5B [cytosol] (Homo sapiens)
eIF5B:GDP [cytosol] (Homo sapiens)
EIF5B [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60841 EIF5B
Gene Names
EIF5B, IF2, KIAA0741
Chain
chain:1-1220
Reference Genes
BioGPS Gene:9669 EIF5B
COSMIC (genes):EIF5B EIF5B
CTD Gene:9669 EIF5B
dbSNP Gene:9669 EIF5B
ENSEMBL:ENSG00000158417 EIF5B
HGNC:30793 EIF5B
KEGG:hsa:9669 EIF5B
Monarch:9669 EIF5B
NCBI Gene:9669 EIF5B
OMIM:606086 EIF5B
UCSC:O60841 EIF5B
Reference Transcript
RefSeq:NM_015904.3 EIF5B
Other Identifiers
11743363_a_at
11743364_a_at
11743365_at
11744531_x_at
16883426
201024_PM_x_at
201024_x_at
201025_PM_at
201025_at
201027_PM_s_at
201027_s_at
214314_PM_s_at
214314_s_at
2495889
2495890
2495891
2495892
2495893
2495901
2495902
2495903
2495904
2495905
2495907
2495908
2495909
2495910
2495911
2495912
2495914
2495915
2495916
2495917
2495918
2495919
2495920
2495921
2495922
2495923
2495924
2495925
2495926
2495927
2495928
2495929
2495930
2495931
2495932
2495933
2495934
2495935
2495936
2495937
2495938
2495939
2495940
2495941
2495946
40537_at
73251_f_at
8043861
9669
A_14_P106552
A_14_P111196
A_23_P218608
GE53452
GO:0000049
GO:0003723
GO:0003743
GO:0003824
GO:0003924
GO:0005515
GO:0005525
GO:0005737
GO:0005829
GO:0006412
GO:0006413
GO:0006446
GO:0016787
GO:0042255
GO:0045182
GO:0045202
GO:0046872
HMNXSV003000653
Hs.158688.0.A1_3p_a_at
Hs.158688.0.A3_3p_at
Hs.158688.1.S1_3p_a_at
ILMN_1756767
PH_hs_0009628
TC02000603.hg
g7706231_3p_a_at
Participates
as a component of
eIF5B:GDP [cytosol] (Homo sapiens)
eIF5B:GTP [cytosol] (Homo sapiens)
Inferred To
Ghost homologue of EIF5B [cytosol]
(Danio rerio)
eIF5B [cytosol]
(Drosophila melanogaster)
eif5b [cytosol]
(Xenopus tropicalis)
iffb-1 [cytosol]
(Caenorhabditis elegans)
EIF5B [cytosol]
(Bos taurus)
EIF5B [cytosol]
(Canis familiaris)
EIF5B [cytosol]
(Dictyostelium discoideum)
EIF5B [cytosol]
(Gallus gallus)
EIF5B [cytosol]
(Mus musculus)
EIF5B [cytosol]
(Plasmodium falciparum)
EIF5B [cytosol]
(Rattus norvegicus)
EIF5B [cytosol]
(Saccharomyces cerevisiae)
EIF5B [cytosol]
(Schizosaccharomyces pombe)
EIF5B [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_056988.3
ENSEMBL
ENST00000289371
,
ENSP00000289371
OpenTargets
ENSG00000158417
IntEnz
3.6.5.3
HPA
ENSG00000158417-EIF5B
PRO
O60841
Pharos - Targets
O60841
GlyGen
O60841
HMDB Protein
HMDBP10760
PDB
7TQL
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:P14921 ETS1
2
ETS1 [nucleoplasm]
(R-HSA-1629809)
p-T38-ETS1 [nucleoplasm]
(R-HSA-3132720)
0.524
2
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