Reactome | RPL41 [cytosol]

RPL41 [cytosol]

Stable Identifier

R-HSA-72478

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

60S ribosomal protein L41, HG12

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
      - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
        
        EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL41 [cytosol] (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL41 [cytosol] (Homo sapiens)
      - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL41 [cytosol] (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL41 [cytosol] (Homo sapiens)
      - IMPACT binds GCN1 (Homo sapiens)
        
        GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL41 [cytosol] (Homo sapiens)
        
        IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL41 [cytosol] (Homo sapiens)
      - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL41 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL41 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL41 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL41 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL41 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL41 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL41 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL41 [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL41 [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL41 [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL41 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62945 RPL41

Gene Names

RPL41

Chain

chain:1-25

Reference Genes

BioGPS Gene:6171 RPL41

COSMIC (genes):RPL41 RPL41

CTD Gene:6171 RPL41

dbSNP Gene:6171 RPL41

ENSEMBL:ENSG00000229117 RPL41

HGNC:10354 RPL41

KEGG Gene (Homo sapiens):6171 RPL41

Monarch:6171 RPL41

NCBI Gene:6171 RPL41

OMIM:613315 RPL41

UCSC:P62945 RPL41

Reference Transcript

Other Identifiers

0006770156

11721113_x_at

11757355_x_at

16752477

17118277

201492_s_at

2810098

2810099

2810100

3026346

3026347

3026348

32466_at

3417346

3417347

3417353

3417354

3417355

3417357

3417358

3417359

3465758

3465759

3465760

3585540

3585542

3752156

3879737

3879738

3959291

3959292

6171

7956159

7965467

7982129

8061364

8075691

8105432

A_14_P115127

A_23_P128067

GE80308

GO:0000184

GO:0002181

GO:0003674

GO:0003723

GO:0003729

GO:0003730

GO:0003735

GO:0005198

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005783

GO:0005829

GO:0005840

GO:0006364

GO:0006412

GO:0006413

GO:0006605

GO:0006614

GO:0006810

GO:0008150

GO:0009056

GO:0009058

GO:0015031

GO:0019083

GO:0022625

GO:0032991

GO:0034641

GO:0034655

GO:0042254

GO:0042788

GO:0043226

GO:0044403

GO:0048027

ILMN_1710001

ILMN_2331890

PH_hs_0029972

TC12000502.hg

TC12001813.hg

TC12002389.hg

TC15000130.hg

TC20000146.hg

Z12962_at

g10863874_3p_s_at

Participates

as a component of

Inferred To

Ghost homologue of RPL41 [cytosol] (Bos taurus)

Ghost homologue of RPL41 [cytosol] (Caenorhabditis elegans)

Ghost homologue of RPL41 [cytosol] (Canis familiaris)

Ghost homologue of RPL41 [cytosol] (Danio rerio)

Ghost homologue of RPL41 [cytosol] (Dictyostelium discoideum)

Ghost homologue of RPL41 [cytosol] (Drosophila melanogaster)

Ghost homologue of RPL41 [cytosol] (Gallus gallus)

Ghost homologue of RPL41 [cytosol] (Mus musculus)

Ghost homologue of RPL41 [cytosol] (Plasmodium falciparum)

Ghost homologue of RPL41 [cytosol] (Rattus norvegicus)

Ghost homologue of RPL41 [cytosol] (Saccharomyces cerevisiae)

Ghost homologue of RPL41 [cytosol] (Schizosaccharomyces pombe)

Ghost homologue of RPL41 [cytosol] (Sus scrofa)

Ghost homologue of RPL41 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001030344.1, NP_066927.1

OpenTargets

ENSG00000229117

HPA

ENSG00000229117-RPL41

GeneCards

P62945

Ensembl

ENSP00000449026, ENST00000501597, ENSP00000420821, ENST00000546591, ENSG00000229117

PRO

P62945

Pharos - Targets

P62945

PDB

6IP6, 6ZON, 7K5I, 6G5H, 7A09, 6QZP, 6IP5, 6Y0G, 5LKS, 6ZM7, 6EK0, 6OLI, 6IP8, 6Z6M, 6ZOJ, 6ZLW, 6XA1, 6ZOK, 6ZMW, 6W6L, 6Z6N, 5AJ0, 6OLF, 6ZMO, 5VYC, 6OLG, 5OA3, 6Y57, 6YBW, 6Y6X, 6ZVJ, 6Z6L, 6ZMI, 4UG0, 6OLE, 6ZME, 4V6X, 6OLZ, 6OM7, 5A2Q, 6Y2L, 6OM0, 6ZP4

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.495	2

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