Reactome | RPL37 [cytosol]

RPL37 [cytosol]

Stable Identifier

R-HSA-72466

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

60S ribosomal protein L37, G1.16

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
      - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
        
        EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL37 [cytosol] (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL37 [cytosol] (Homo sapiens)
      - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL37 [cytosol] (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL37 [cytosol] (Homo sapiens)
      - IMPACT binds GCN1 (Homo sapiens)
        
        GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL37 [cytosol] (Homo sapiens)
        
        IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL37 [cytosol] (Homo sapiens)
      - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL37 [cytosol] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Influenza Infection (Homo sapiens)
      - Influenza Viral RNA Transcription and Replication (Homo sapiens)
        
        Viral mRNA Translation (Homo sapiens)
        
        Synthesis of PB1-F2 (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL37 [cytosol] (Homo sapiens)
        
        Viral Protein Synthesis (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL37 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL37 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL37 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL37 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL37 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL37 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL37 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL37 [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL37 [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL37 [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL37 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P61927 RPL37

Gene Names

RPL37

Chain

chain:1-97

Reference Genes

BioGPS Gene:6167 RPL37

COSMIC (genes):RPL37 RPL37

CTD Gene:6167 RPL37

dbSNP Gene:6167 RPL37

ENSEMBL:ENSG00000145592 RPL37

HGNC:10347 RPL37

KEGG:hsa:6167 RPL37

Monarch:6167 RPL37

NCBI Gene:6167 RPL37

OMIM:604181 RPL37

UCSC:P61927 RPL37

Reference Transcript

RefSeq:NM_000997.4 RPL37

Other Identifiers

11733774_a_at

11744326_s_at

11757424_x_at

11759112_at

11759113_at

11759114_at

16651347

16651353

16651355

16995705

16995715

16995717

18670203

18670204

18670205

18670206

18670207

18670208

18670209

18670210

18670211

200092_PM_s_at

200092_s_at

224763_PM_at

224763_at

224766_PM_at

224766_at

224767_PM_at

224767_at

2854787

2854789

2854791

2854792

2854793

2854794

2854795

2854796

2854797

2854798

2854799

2854800

2854801

2854802

2854803

2854804

2854805

2854806

2854807

2854808

2854809

2854810

2854811

2854812

2854813

3099177

33656_at

52614_at

6167

68359_at

8111814

82154_at

A_21_P0000267

A_21_P0000684

A_24_P20777

A_24_P371738

A_33_P3261246

GE80124

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005737

GO:0005829

GO:0005840

GO:0006412

GO:0019843

GO:0022625

GO:0022626

GO:0043226

GO:0046872

GO:0097371

GO:0098772

GO:1901798

GO:1990904

GO:1990948

HMNXSV003011294

HMNXSV003020358

HMNXSV003054771

Hs.179779.1.S1_3p_a_at

Hs.80545.1.A1_3p_at

Hs.80545.1.A2_3p_at

Hs.80545.1.A3_3p_at

ILMN_1800796

ILMN_2191634

PH_hs_0029003

PH_hs_0039590

RNA33657|snoRNA_scaRNA_253_80

TC05001300.hg

TC05001301.hg

TC05002974.hg

TC05002975.hg

p25330

Participates

as a component of

Inferred To

RPL37 [cytosol] (Bos taurus)

RPL37 [cytosol] (Dictyostelium discoideum)

RPL37 [cytosol] (Drosophila melanogaster)

RPL37 [cytosol] (Gallus gallus)

RPL37 [cytosol] (Mus musculus)

RPL37 [cytosol] (Plasmodium falciparum)

RPL37 [cytosol] (Rattus norvegicus)

RPL37 [cytosol] (Saccharomyces cerevisiae)

RPL37 [cytosol] (Schizosaccharomyces pombe)

RPL37 [cytosol] (Sus scrofa)

Homologues of RPL37 [cytosol] (Rattus norvegicus)

Homologues of RPL37 [cytosol] (Saccharomyces cerevisiae)

rpl-37.1 [cytosol] (Caenorhabditis elegans)

LOC120097744 [cytosol] (Rattus norvegicus)

rpl37 [cytosol] (Xenopus tropicalis)

LOC119863879 [cytosol] (Canis familiaris)

Ghost homologue of RPL37 [cytosol] (Danio rerio)

Cross References

OpenTargets

ENSG00000145592

ENSEMBL

ENSP00000274242, ENST00000274242, ENSG00000145592

HPA

ENSG00000145592-RPL37

GeneCards

RPL37

PRO

P61927

Pharos - Targets

P61927

GlyGen

P61927

PDB

6IP5, 8FKZ, 8G6J, 8FLB, 8FKT, 8XSX, 8FL6, 9G8M, 6Y0G, 6LU8, 8G61, 8IPY, 8FL2, 8JDK, 8K2C, 6Y2L, 6XA1, 8Y0X, 6OLE, 8INK, 8IPX, 8OJ8, 9GMO, 6Z6N, 6IP6, 8FKQ, 8IR1, 8FLA, 8IFE, 7XNY, 5LKS, 8FKV, 4UG0, 8IR3, 8FKW, 8IDY, 8YOP, 8A3D, 8IPD, 8IDT, 6LQM, 8FL4, 8G60, 8FLC, 6OLF, 8JDJ, 6OLI, 6Z6L, 6LSS, 8OHD, 8IFD, 8INE, 8FLD, 8FKR, 8XSZ, 8IE3, 8FL7, 8FKP, 8FKX, 6Y57, 6OLZ, 6IP8, 6ZM7, 6Y6X, 8Y0W, 5AJ0, 8JDM, 8G5Z, 8G5Y, 8OJ0, 6ZMI, 7OW7, 6LSR, 5T2C, 7XNX, 8XSY, 8FLE, 6OM7, 8FKY, 8FKS, 8FKU, 8FL9, 8YOO, 7BHP, 8FLF, 8GLP, 8FL3, 4V6X, 6OLG, 6W6L, 6ZME, 8JDL, 6ZMO, 8INF, 6OM0, 6Z6M, 6QZP, 8QOI, 7F5S, 8OJ5

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63244 RACK1	1	RACK1 [cytosol] (R-HSA-5626956)	0.495	2

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