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GSR-2 [cytosol]
Stable Identifier
R-HSA-71679
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
glutathione reductase, GSHR_HUMAN, Glutathione reductase, mitochondrial precursor , GRase, GR, GSR isoform 2
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Detoxification of Reactive Oxygen Species (Homo sapiens)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Homo sapiens)
GSR-2:FAD dimer [cytosol] (Homo sapiens)
GSR-2 [cytosol] (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Homo sapiens)
NFE2L2-dependent GSR gene expression (Homo sapiens)
GSR-2:FAD dimer [cytosol] (Homo sapiens)
GSR-2 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Homo sapiens)
GSR-2:FAD dimer [cytosol] (Homo sapiens)
GSR-2 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Selenoamino acid metabolism (Homo sapiens)
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se (Homo sapiens)
GSSeSG is reduced to GSSeH and GSH by GSR (Homo sapiens)
GSR-2:FAD dimer [cytosol] (Homo sapiens)
GSR-2 [cytosol] (Homo sapiens)
Metabolism of nucleotides (Homo sapiens)
Interconversion of nucleotide di- and triphosphates (Homo sapiens)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Homo sapiens)
GSR-2:FAD dimer [cytosol] (Homo sapiens)
GSR-2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P00390-2 GSR
Gene Names
GSR, GLUR, GRD1
Participates
as a component of
GSR-2:FAD dimer [cytosol] (Homo sapiens)
Inferred To
gsr [cytosol]
(Xenopus tropicalis)
GSR-2 [cytosol]
(Bos taurus)
GSR-2 [cytosol]
(Caenorhabditis elegans)
GSR-2 [cytosol]
(Canis familiaris)
GSR-2 [cytosol]
(Dictyostelium discoideum)
GSR-2 [cytosol]
(Gallus gallus)
GSR-2 [cytosol]
(Mus musculus)
GSR-2 [cytosol]
(Plasmodium falciparum)
GSR-2 [cytosol]
(Saccharomyces cerevisiae)
GSR-2 [cytosol]
(Schizosaccharomyces pombe)
GSR-2 [cytosol]
(Sus scrofa)
Gsr [cytosol]
(Rattus norvegicus)
Cross References
Guide to Pharmacology - Targets
2613
OpenTargets
ENSG00000104687
ENSEMBL
ENSP00000445516
,
ENST00000541648
,
ENSP00000444559
,
ENST00000221130
,
ENST00000546342
,
ENSG00000104687
,
ENSP00000438845
,
ENSP00000221130
,
ENST00000537535
ZINC - FDA approved
GSHR_HUMAN
ZINC - Substances
GSHR_HUMAN
ZINC target
P00390
PRO
P00390
GlyGen
P00390
PDB
4GRT
,
2GRT
,
1K4Q
,
1GSN
,
3DK9
,
2GH5
,
1BWC
,
2AAQ
,
1GRT
,
3GRS
,
3DK8
,
3GRT
,
5GRT
,
3DK4
,
3DJG
,
1GRE
,
1DNC
,
4GR1
,
1GRF
,
1GRG
,
1GRH
,
1ALG
,
3DJJ
,
1XAN
,
1GRA
,
1GRB
,
3SQP
IntEnz
1.8.1.7
HPA
ENSG00000104687-GSR
GeneCards
GSR
Pharos - Targets
P00390
Orphanet
GSR
ZINC - Predictions - Purchasable
GSHR_HUMAN
HMDB Protein
HMDBP00196
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