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GSR-2 [cytosol]
Stable Identifier
R-HSA-71679
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
glutathione reductase, GSHR_HUMAN, Glutathione reductase, mitochondrial precursor , GRase, GR, GSR isoform 2
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Detoxification of Reactive Oxygen Species (Homo sapiens)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Homo sapiens)
GSR-2:FAD dimer [cytosol] (Homo sapiens)
GSR-2 [cytosol] (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Homo sapiens)
NFE2L2-dependent GSR gene expression (Homo sapiens)
GSR-2:FAD dimer [cytosol] (Homo sapiens)
GSR-2 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Homo sapiens)
GSR-2:FAD dimer [cytosol] (Homo sapiens)
GSR-2 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Selenoamino acid metabolism (Homo sapiens)
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se (Homo sapiens)
GSSeSG is reduced to GSSeH and GSH by GSR (Homo sapiens)
GSR-2:FAD dimer [cytosol] (Homo sapiens)
GSR-2 [cytosol] (Homo sapiens)
Metabolism of nucleotides (Homo sapiens)
Interconversion of nucleotide di- and triphosphates (Homo sapiens)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Homo sapiens)
GSR-2:FAD dimer [cytosol] (Homo sapiens)
GSR-2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P00390-2 GSR
Gene Names
GSR, GLUR, GRD1
Other Identifiers
11756634_a_at
11759080_at
17076063
205770_PM_at
205770_at
225609_PM_at
225609_at
2936
3130162
3130163
3130164
3130166
3130168
3130169
3130171
3130172
3130174
3130177
3130178
3130179
3130181
3130182
3130188
3130189
3130190
3130191
3130192
35130_at
63787_i_at
8150112
A_23_P146084
A_32_P31618
GE54991
GO:0000166
GO:0003824
GO:0004362
GO:0005576
GO:0005615
GO:0005737
GO:0005739
GO:0005759
GO:0005829
GO:0005886
GO:0006091
GO:0006575
GO:0006749
GO:0006790
GO:0009055
GO:0009897
GO:0016209
GO:0016491
GO:0016668
GO:0022900
GO:0034599
GO:0043226
GO:0045454
GO:0050660
GO:0050661
GO:0070062
GO:0098754
GO:0098869
GO:0140096
HMNXSV003002640
Hs.193974.0.S1_3p_at
ILMN_1775182
ILMN_2127416
PH_hs_0024978
PH_hs_0033237
TC08001110.hg
X15722_at
g10835188_3p_at
Participates
as a component of
GSR-2:FAD dimer [cytosol] (Homo sapiens)
Inferred To
gsr [cytosol]
(Xenopus tropicalis)
GSR-2 [cytosol]
(Bos taurus)
GSR-2 [cytosol]
(Caenorhabditis elegans)
GSR-2 [cytosol]
(Canis familiaris)
GSR-2 [cytosol]
(Danio rerio)
GSR-2 [cytosol]
(Dictyostelium discoideum)
GSR-2 [cytosol]
(Gallus gallus)
GSR-2 [cytosol]
(Mus musculus)
GSR-2 [cytosol]
(Plasmodium falciparum)
GSR-2 [cytosol]
(Saccharomyces cerevisiae)
GSR-2 [cytosol]
(Schizosaccharomyces pombe)
GSR-2 [cytosol]
(Sus scrofa)
Gsr [cytosol]
(Rattus norvegicus)
Homologues of GSR-2 [cytosol]
(Plasmodium falciparum)
Cross References
RefSeq
NP_001182033.1
,
NP_001182031.1
,
NP_000628.2
,
NP_001182032.1
ZINC - World Drugs
GSHR_HUMAN
Guide to Pharmacology - Targets
2613
OpenTargets
ENSG00000104687
ZINC - FDA approved
GSHR_HUMAN
ZINC - Substances
GSHR_HUMAN
ZINC target
P00390
PRO
P00390
PDB
1XAN
,
5GRT
,
1GSN
,
3DJG
,
1BWC
,
1DNC
,
1GRH
,
3DK4
,
1GRE
,
3GRT
,
3SQP
,
2GH5
,
1GRB
,
3GRS
,
4GR1
,
3DK9
,
1GRG
,
1ALG
,
2AAQ
,
1K4Q
,
1GRA
,
3DJJ
,
2GRT
,
4GRT
,
3DK8
,
1GRF
,
1GRT
IntEnz
1.8.1.7
HPA
ENSG00000104687-GSR
GeneCards
P00390
Ensembl
ENST00000541648
,
ENSG00000104687
,
ENSP00000438845
,
ENSP00000445516
,
ENSP00000221130
,
ENST00000537535
,
ENST00000546342
,
ENSP00000444559
,
ENST00000221130
Pharos - Targets
P00390
ZINC - Predictions - Purchasable
GSHR_HUMAN
Orphanet
16171
HMDB Protein
HMDBP00196
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