Reactome | PGAM dimers isomerise 2PG to 3PG

PGAM dimers isomerise 2PG to 3PG

Stable Identifier

R-HSA-71445

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

2R)-2-phosphoglycerate => (2R)-3-phosphoglycerate

ReviewStatus

5/5

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Cytosolic phosphoglycerate mutase dimers (PGAM1,2) catalyze the reversible isomerisation of 2- and 3-phosphoglycerate (2PG; 3PG). There are two isoforms of this enzyme, PGAM1 (isoform B) and PGAM2 (isoform M). In the body, erythrocytes express only PGAM1, while skeletal muscle expresses only PGAM2. Other tissues express both isoforms (Omenn & Cheung 1974; Repiso et al. 2005; Tsujino et al. 1993).

Literature References

PubMed ID	Title	Journal	Year
4827367	Phosphoglycerate mutase isozyme marker for tissue differentiation in man Omenn, GS, Cheung, SC	Am J Hum Genet	1974
15710582	Phosphoglycerate mutase BB isoenzyme deficiency in a patient with non-spherocytic anemia: familial and metabolic studies Repiso, A, Baso, MJR, Corrons, J-LV, Carreras, J, Climent, F	Haematologica	2005
8447317	The molecular genetic basis of muscle phosphoglycerate mutase (PGAM) deficiency Tsujino, S, Shanske, S, Sakoda, S, Fenichel, G, DiMauro, S	Am J Hum Genet	1993