2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate

Stable Identifier
R-HSA-71445
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
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Cytosolic phosphoglycerate mutase dimer catalyzes the reversible isomerisation of 2- and 3-phosphoglycerate. There are two isoforms of this enzyme, PGAM1 (isoform B) and PGAM2 (isoform M). In the body, erythrocytes express only PGAM1, while skeletal muscle expresses only PGAM2. Other tissues express both isoforms (Repiso et al. 2005; Tsujino et al. 1993).

Literature References
PubMed ID Title Journal Year
15710582 Phosphoglycerate mutase BB isoenzyme deficiency in a patient with non-spherocytic anemia: familial and metabolic studies

Baso, MJR, Repiso, A, Climent, F, Corrons, J-LV, Carreras, J

Haematologica 2005
8447317 The molecular genetic basis of muscle phosphoglycerate mutase (PGAM) deficiency

Fenichel, G, Sakoda, S, Tsujino, S, DiMauro, S, Shanske, S

Am J Hum Genet 1993
Participants
Output
Participates
Catalyst Activity

phosphoglycerate mutase activity of PGAM dimers [cytosol]

Orthologous Events
Cross References
Rhea
Reviewed
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