2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate

Stable Identifier
R-HSA-71445
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic phosphoglycerate mutase dimer catalyzes the reversible isomerisation of 2- and 3-phosphoglycerate. There are two isoforms of this enzyme, PGAM1 (isoform B) and PGAM2 (isoform M). In the body, erythrocytes express only PGAM1, while skeletal muscle expresses only PGAM2. Other tissues express both isoforms (Repiso et al. 2005; Tsujino et al. 1993).

Literature References
PubMed ID Title Journal Year
8447317 The molecular genetic basis of muscle phosphoglycerate mutase (PGAM) deficiency

Tsujino, S, Shanske, S, Sakoda, S, Fenichel, G, DiMauro, S

Am J Hum Genet 1993
15710582 Phosphoglycerate mutase BB isoenzyme deficiency in a patient with non-spherocytic anemia: familial and metabolic studies

Repiso, A, Baso, MJR, Corrons, J-LV, Carreras, J, Climent, F

Haematologica 2005
Participants
Participant Of
hasEvent
Event Information
Catalyst Activity
Catalyst Activity
Title
phosphoglycerate mutase activity of PGAM dimers [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Reviewed