2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate

Stable Identifier
R-HSA-71445
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate
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Cytosolic phosphoglycerate mutase dimer catalyzes the reversible isomerisation of 2- and 3-phosphoglycerate. There are two isoforms of this enzyme, PGAM1 (isoform B) and PGAM2 (isoform M). In the body, erythrocytes express only PGAM1, while skeletal muscle expresses only PGAM2. Other tissues express both isoforms (Repiso et al. 2005; Tsujino et al. 1993).

Literature References
PubMed ID Title Journal Year
8447317 The molecular genetic basis of muscle phosphoglycerate mutase (PGAM) deficiency

Tsujino, S, Shanske, S, Sakoda, S, Fenichel, G, DiMauro, S

Am J Hum Genet 1993
15710582 Phosphoglycerate mutase BB isoenzyme deficiency in a patient with non-spherocytic anemia: familial and metabolic studies

Repiso, A, Baso, MJR, Corrons, J-LV, Carreras, J, Climent, F

Haematologica 2005
Participants
Input
Output
Participant Of
hasEvent
Event Information
Reverse Reaction
3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Homo sapiens)
Catalyst Activity
Catalyst Activity
Title
phosphoglycerate mutase activity of PGAM dimers [cytosol]
Physical Entity
PGAM dimers [cytosol]
Activity
phosphoglycerate mutase activity (0004619)
Orthologous Events
2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Bos taurus)
2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Canis familiaris)
2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Danio rerio)
2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Dictyostelium discoideum)
2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Drosophila melanogaster)
2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Mus musculus)
2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Plasmodium falciparum)
2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Rattus norvegicus)
2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Schizosaccharomyces pombe)
2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Sus scrofa)
2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate (Xenopus tropicalis)
Cross References
Rhea
Reviewed
Harris, RA  (2008-09-10)