Reactome | PGD decarboxylates 6-phospho-D-gluconate

PGD decarboxylates 6-phospho-D-gluconate

Stable Identifier

R-HSA-71299

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+

ReviewStatus

5/5

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PGD decarboxylates 6-phospho-D-gluconate

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Cytosolic phosphogluconate dehydrogenase (PGD) catalyzes the reaction of 6-phospho-D-gluconate and NADP+ to form D-ribulose 5-phosphate, CO2, and NADPH + H+ (Beutler and Kuhl 1985; Rippa et al. 1998). The PGD enzyme is dimeric (Dallocchio et al. 1985).

Literature References

PubMed ID	Title	Journal	Year
3994686	Half-site reactivity in 6-phosphogluconate dehydrogenase from human erythrocytes Dallocchio, F, Matteuzzi, M, Bellini, T	Biochem J	1985
3932573	Limiting role of 6-phosphogluconolactonase in erythrocyte hexose monophosphate pathway metabolism Beutler, E, Kuhl, W	J Lab Clin Med	1985
9920387	6-Phosphogluconate dehydrogenase: the mechanism of action investigated by a comparison of the enzyme from different species Rippa, M, Giovannini, PP, Barrett, MP, Dallocchio, F, Hanau, S	Biochim Biophys Acta	1998