6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+

Stable Identifier
R-HSA-71299
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+
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Cytosolic phosphogluconate dehydrogenase (PGD) catalyzes the reaction of 6-phospho-D-gluconate and NADP+ to form D-ribulose 5-phosphate, CO2, and NADPH + H+ (Beutler and Kuhl 1985; Rippa et al. 1998). The PGD enzyme is dimeric (Dallocchio et al. 1985).

Literature References
PubMed ID Title Journal Year
3994686 Half-site reactivity in 6-phosphogluconate dehydrogenase from human erythrocytes

Dallocchio, F, Bellini, T, Matteuzzi, M

Biochem J 1985
3932573 Limiting role of 6-phosphogluconolactonase in erythrocyte hexose monophosphate pathway metabolism

Kuhl, W, Beutler, E

J Lab Clin Med 1985
9920387 6-Phosphogluconate dehydrogenase: the mechanism of action investigated by a comparison of the enzyme from different species

Dallocchio, F, Hanau, S, Giovannini, PP, Barrett, MP, Rippa, M

Biochim Biophys Acta 1998
Participants
Input
Output
Participates
as an event of
Catalyst Activity

phosphogluconate dehydrogenase (decarboxylating) activity of PGD dimer [cytosol]

Physical Entity
PGD dimer [cytosol] (Homo sapiens)
Activity
phosphogluconate dehydrogenase (decarboxylating) activity (GO:0004616)
Orthologous Events
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Bos taurus)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Caenorhabditis elegans)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Canis familiaris)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Danio rerio)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Dictyostelium discoideum)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Drosophila melanogaster)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Gallus gallus)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Mus musculus)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Rattus norvegicus)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Saccharomyces cerevisiae)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Schizosaccharomyces pombe)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Sus scrofa)
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Xenopus tropicalis)
Cross References
Rhea
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